来自柱孢霉的大麻二酚和8-氯大麻二酚酸作为真菌拮抗剂。

Cannabiorci- and 8-chlorocannabiorcichromenic acid as fungal antagonists from Cylindrocarpon olidum.

作者信息

Quaghebeur K, Coosemans J, Toppet S, Compernolle F

机构信息

Faculty of Agricultural and Applied Biological Sciences, K. U. Leuven, Belgium.

出版信息

Phytochemistry. 1994 Sep;37(1):159-61. doi: 10.1016/0031-9422(94)85016-x.

DOI:10.1016/0031-9422(94)85016-x

PMID:7765609

Abstract

Cannabiorcichromenic acid and 8-chlorocannabiorcichromenic acid [8-chloro-5-hydroxy-2,7-dimethyl-2-(4-methyl-3-pentenyl)-2H-1-benzopyran -6- carboxylic acid] were identified as active components in cultures of Cylindrocarpon olidum which antagonized various other fungi. Experiments performed with the purified acids confirmed the antifungal activity; in addition, they revealed that the acids had antibiotic properties towards gram-positive bacteria and were toxic to nematodes.

摘要

大麻奥氏色烯酸和8-氯大麻奥氏色烯酸[8-氯-5-羟基-2,7-二甲基-2-(4-甲基-3-戊烯基)-2H-1-苯并吡喃-6-羧酸]被鉴定为拮抗其他多种真菌的柱孢属真菌培养物中的活性成分。用纯化后的酸进行的实验证实了其抗真菌活性；此外，实验还表明这些酸对革兰氏阳性菌具有抗菌特性，并且对线虫有毒性。