细胞松素 Y 和 Z，真菌菌株 Trichoderma sp. FKI-6626 产生的新型抗真菌聚酮化合物。
Cytosporones Y and Z, new antifungal polyketides produced by the fungal strain Trichoderma sp. FKI-6626.
机构信息
Graduate School of Infection Control Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo, 108-8641, Japan.
Ōmura Satoshi Memorial Institute, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo, 108-8641, Japan.
出版信息
J Antibiot (Tokyo). 2024 Nov;77(11):721-726. doi: 10.1038/s41429-024-00765-9. Epub 2024 Sep 6.
Two new antifungal polyketides, named cytosporones Y (1) and Z (2), were discovered from the cultured broth of Trichoderma sp. FKI-6626. Their structures were elucidated by MS and NMR analysis. Both compounds exhibited antifungal activity against five Aspergillus species, the causative agents of aspergillosis.
从 Trichoderma sp. FKI-6626 的发酵液中分离得到了两个新的抗真菌聚酮化合物，命名为细胞色素酮 Y（1）和 Z（2）。通过 MS 和 NMR 分析阐明了它们的结构。这两种化合物对引起曲霉病的五种曲霉菌均具有抗真菌活性。
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