Buffalo E A, Ramus S J, Squire L R, Zola S M
Department of Neurosciences, UCSD, La Jolla, California 92093, USA.
Learn Mem. 2000 Nov-Dec;7(6):375-82. doi: 10.1101/lm.32100.
Monkeys with lesions of perirhinal cortex (PR group) and monkeys with lesions of inferotemporal cortical area TE (TE group) were tested on a modified version of the delayed nonmatching to sample (DNMS) task that included very short delay intervals (0.5 sec) as well as longer delay intervals (1 min and 10 min). Lesions of the perirhinal cortex and lesions of area TE produced different patterns of impairment. The PR group learned the DNMS task as quickly as normal monkeys (N) when the delay between sample and choice was very short (0.5 sec). However, performance of the PR group, unlike that of the N group, fell to chance levels when the delay between sample and choice was lengthened to 10 min. In contrast to the PR group, the TE group was markedly impaired on the DNMS task even at the 0.5-sec delay, and three of four monkeys with TE lesions failed to acquire the task. The results provide support for the idea that perirhinal cortex is important not for perceptual processing, but for the formation and maintenance of long-term memory. Area TE is important for the perceptual processing of visual stimuli.
对患有鼻周皮质损伤的猴子（PR组）和患有颞下皮质区TE损伤的猴子（TE组）进行了改良版的延迟非匹配样本（DNMS）任务测试，该任务包括非常短的延迟间隔（0.5秒）以及较长的延迟间隔（1分钟和10分钟）。鼻周皮质损伤和TE区损伤产生了不同的损伤模式。当样本与选择之间的延迟非常短时（0.5秒），PR组学习DNMS任务的速度与正常猴子（N组）一样快。然而，与N组不同的是，当样本与选择之间的延迟延长到10分钟时，PR组的表现降至随机水平。与PR组相反，即使在0.5秒的延迟下，TE组在DNMS任务上也明显受损，并且四只患有TE损伤的猴子中有三只未能学会该任务。这些结果支持了这样一种观点，即鼻周皮质并非对知觉加工很重要，而是对长期记忆的形成和维持很重要。TE区对视觉刺激的知觉加工很重要。
