伴有路易体痴呆共病的快速眼动睡眠行为障碍的病理学
The pathology of REM sleep behavior disorder with comorbid Lewy body dementia.
作者信息
Turner R S, D'Amato C J, Chervin R D, Blaivas M
机构信息
Veterans Administration Medical Center Geriatric Research Education and Clinical Center, Ann Arbor, MI 48105, USA.
出版信息
Neurology. 2000 Dec 12;55(11):1730-2. doi: 10.1212/wnl.55.11.1730.
A patient with REM sleep behavior disorder who subsequently developed probable Lewy body dementia is now reported to have a definite pathologic diagnosis of Lewy body dementia. Examination of brain revealed Lewy bodies as well as marked neuronal loss in brainstem monoaminergic nuclei-particularly locus coeruleus and substantia nigra-that inhibit cholinergic neurons in the pedunculopontine nucleus mediating atonia during REM sleep.
据报道，一名患有快速眼动睡眠行为障碍且随后发展为可能的路易体痴呆症的患者，现已确诊为路易体痴呆症。脑部检查发现路易小体，以及脑干单胺能核团（特别是蓝斑和黑质）中明显的神经元丢失，这些核团在快速眼动睡眠期间抑制脚桥核中的胆碱能神经元，从而介导肌张力缺失。
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