Uchiyama M, Isse K, Tanaka K, Yokota N, Hamamoto M, Aida S, Ito Y, Yoshimura M, Okawa M
Department of Psychophysiology, National Institute of Mental Health, NCNP, Ichikawa-City, Japan.
Neurology. 1995 Apr;45(4):709-12. doi: 10.1212/wnl.45.4.709.
We studied an 84-year-old man with a 20-year history of nocturnal violent behavior during sleep, but no other clinically evident neuropsychiatric disorders. Polysomnographic investigations confirmed that he suffered from REM sleep behavior disorder (RBD). Histopathologic examination revealed he had Lewy body disease with a marked decrease of pigmented neurons in the locus ceruleus and substantia nigra. These histologic findings represent the first documented evidence of a loss of brainstem monoaminergic neurons in clinically idiopathic RBD and suggest that Lewy body disease might provide an explanation for idiopathic RBD in the aged.
我们研究了一名84岁男性，其有20年睡眠期间夜间暴力行为史，但无其他临床上明显的神经精神障碍。多导睡眠图检查证实他患有快速眼动睡眠行为障碍（RBD）。组织病理学检查显示他患有路易体病，蓝斑和黑质中色素神经元明显减少。这些组织学发现是临床上特发性RBD中脑干单胺能神经元丧失的首个记录证据，并表明路易体病可能为老年人特发性RBD提供一种解释。
