Boyce T G, Mellen B G, Mitchel E F, Wright P F, Griffin M R
Department of Pediatric and Adolescent Medicine, Mayo Clinic and Mayo Medical School, Rochester, Minnesota 55905, USA.
J Pediatr. 2000 Dec;137(6):865-70. doi: 10.1067/mpd.2000.110531.
To determine rates of hospitalization associated with respiratory syncytial virus (RSV) infection among children with and without specific medical conditions.
Retrospective cohort study of all children <3 years old enrolled in the Tennessee Medicaid program from July 1989 through June 1993 (248,652 child-years).
During the first year of life, the estimated number of RSV hospitalizations per 1000 children was 388 for those with bronchopulmonary dysplasia, 92 for those with congenital heart disease, 70 for children born at < or = 28 weeks' gestation, 66 for those born at 29 to <33 weeks, 57 for those born at 33 to <36 weeks, and 30 for children born at term with no underlying medical condition. In the second year of life, children with bronchopulmonary dysplasia had an estimated 73 RSV hospitalizations per 1000 children, whereas those with congenital heart disease had 18 and those with prematurity 16 per 1000. Overall, 53% of RSV hospitalizations occurred in healthy children born at term.
Children with bronchopulmonary dysplasia have high rates of RSV hospitalization until 24 months of age. In contrast, after the first year of life, children with congenital heart disease or prematurity have rates no higher than that of children at low risk who are <12 months old.
确定患有和未患有特定疾病的儿童中与呼吸道合胞病毒（RSV）感染相关的住院率。
对1989年7月至1993年6月参加田纳西医疗补助计划的所有3岁以下儿童进行回顾性队列研究（共248,652儿童年）。
在出生后的第一年，每1000名患有支气管肺发育不良的儿童中，估计RSV住院人数为388人；患有先天性心脏病的儿童为92人；孕周小于或等于28周的儿童为70人；孕周为29至小于33周的儿童为66人；孕周为33至小于36周的儿童为57人；足月出生且无基础疾病的儿童为30人。在出生后的第二年，每1000名患有支气管肺发育不良的儿童中，估计RSV住院人数为73人；患有先天性心脏病的儿童为18人；早产儿童为16人。总体而言，53%的RSV住院发生在足月出生的健康儿童中。
支气管肺发育不良的儿童在24个月龄前RSV住院率较高。相比之下，在出生后的第一年之后，患有先天性心脏病或早产的儿童的住院率不高于12个月龄以下低风险儿童。
