Penumarthy L, Oehme F W
Am J Vet Res. 1975 Feb;36(2):209-12.
Ethylene glycol (EG) was orally administered to 27 cats at dose levels of 4, 6, or 8 ml/kg of body weight. Treatment was initiated 4 or 8 hours later and consisted of giving (intraperitoneal injection, IP) 5 ml of 20% ethanol in isotonic saline solution and 6 ml of 5% sodium bicarbonate in isotonic saline solution per kilogram of body weight. Treatment was repeated every 6 or 8 hours for approximately 56 hours after initial treatment was given. The 6 control cats (i.e., untreated) and all cats treated 8 hours after EG was given in doses of 6 ml/kg (4 cats) or 8 ml/kg (4 cats) died. Only 1 of 4 cats (25%) recovered in the group given EG at the dose level of 4 ml/kg of body weight and initial treatment started 8 hours later. Two of 3 cats (67%) recovered in each of the groups given EG at the dose levels of 4 ml/kg and 6 ml/kg and initially treated 4 hours after dosing, but only 1 of 3 cats (33%) recovered in the group given 8 ml of eg/kg and first treated 4 hours later. Limitations of successful treatment are high doses of EG and delays in initiating the treatment.
给27只猫口服乙二醇（EG），剂量为4、6或8毫升/千克体重。4或8小时后开始治疗，治疗方法为每千克体重腹腔注射（IP）5毫升20%乙醇的等渗盐溶液和6毫升5%碳酸氢钠的等渗盐溶液。首次治疗后，每6或8小时重复治疗一次，持续约56小时。6只对照猫（即未治疗）以及所有在给予6毫升/千克（4只猫）或8毫升/千克（4只猫）剂量的EG后8小时接受治疗的猫均死亡。在给予4毫升/千克体重剂量的EG且8小时后开始首次治疗的组中，4只猫只有1只（25%）康复。在给予4毫升/千克和6毫升/千克剂量的EG且给药后4小时开始首次治疗的每组中，3只猫有2只（67%）康复，但在给予8毫升/千克EG且4小时后开始首次治疗的组中，3只猫只有1只（33%）康复。成功治疗的局限性在于EG剂量高以及治疗开始延迟。
