Pimentel J C, Menezes A P
Am Rev Respir Dis. 1975 Feb;111(2):189-95. doi: 10.1164/arrd.1975.111.2.189.
In a previous publication the writers described a new pulmonary disease in rural workers who sprayed vineyards with Bordeaux Mixture, a copper sulfate solution neutralized with hydrated lime for the prevention of mildew. The study of the liver of these patients at autopsy and percutaneous biopsy revealed histiocytic and noncaseating granulomas containing inclusions of copper, identified by histochemical techniques. The occupational exposure to copper sulfate, the characteristic pulmonary lesions of vineyard sprayer's lung, and the presence of copper in the liver of these patients define this new variety of hepatic granulomatosis.
在之前的一篇出版物中，作者描述了一种发生在农村工人中的新型肺部疾病，这些工人用波尔多液（一种用熟石灰中和的硫酸铜溶液，用于预防霉菌）喷洒葡萄园。对这些患者的肝脏进行尸检和经皮活检研究发现，组织化学技术鉴定出含有铜包涵体的组织细胞性和非干酪样肉芽肿。职业性接触硫酸铜、葡萄园喷雾工肺的特征性肺部病变以及这些患者肝脏中铜的存在，定义了这种新型肝肉芽肿病。
