Grütter M G
Institute of Biochemistry, University of Zürich, Winterthurerstrasse 190, 8057, Zürich, Switzerland.
Curr Opin Struct Biol. 2000 Dec;10(6):649-55. doi: 10.1016/s0959-440x(00)00146-9.
Research in apoptosis has established a central role for caspases. The recent determination of structures of caspase-1, caspase-3 and caspase-8, together with biochemical studies, has greatly enhanced our understanding of the structure, function and specificity of these enzymes. This provides a basis for the further elucidation of the biological role of caspases and a guide to the design of selective inhibitors to treat caspase-mediated diseases.
细胞凋亡研究已确定半胱天冬酶起核心作用。最近对半胱天冬酶 -1、半胱天冬酶 -3 和半胱天冬酶 -8 的结构测定，以及生化研究，极大地增进了我们对这些酶的结构、功能和特异性的理解。这为进一步阐明半胱天冬酶的生物学作用提供了基础，并为设计治疗半胱天冬酶介导疾病的选择性抑制剂提供了指导。
