Hernández R, del Cañizo M C, López C, González M I, Vázquez M L, Caballero M D, San Miguel J F
Servicio de Hematología, Hospital Universitario de Salamanca, Spain.
Med Oncol. 2000 Nov;17(4):337-9. doi: 10.1007/BF02782201.
Pathological rupture of the spleen is a rare but well recognized complication in hematological malignancies. Early clinical recognition of this life-threatening complication is necessary for rapid intervention. Here, we report on the case of a 26-year-old woman with acute promyelocytic leukemia who presented rupture of the spleen on day +2 of treatment with ATRA plus idarrubicin. In patients with acute leukemia, the presence of a painful abdomen and a sudden drop in hemoglobin levels, should alert of a possible splenic rupture, even without additional symptoms. This would facilitate an early treatment intervention with no modification to the chemotherapy schedule.
脾脏病理性破裂是血液系统恶性肿瘤中一种罕见但已得到充分认识的并发症。早期临床识别这种危及生命的并发症对于迅速干预至关重要。在此，我们报告一例26岁急性早幼粒细胞白血病女性患者，在全反式维甲酸（ATRA）加伊达比星治疗第2天出现脾脏破裂。对于急性白血病患者，即使没有其他症状，出现腹痛和血红蛋白水平突然下降也应警惕可能的脾破裂。这将有助于在不改变化疗方案的情况下进行早期治疗干预。
