Zhang Yue, Zhang Juan, Chen Tingting, Zeng Hui, Zhao Bing, Zhang Yong, Zhou Xiaohuan, Han Wei, Hu Yanping, Liu Fengge, Shan Zhijuan, Gao Weifeng, Zhou Hebing
Department of Hematology, Luhe Hospital, Capital Medical University, Beijing 101149, P.R. China.
Department of General Surgery, Luhe Hospital, Capital Medical University, Beijing 101149, P.R. China.
Mol Clin Oncol. 2017 Feb;6(2):209-213. doi: 10.3892/mco.2016.1120. Epub 2016 Dec 28.
Spontaneous splenic rupture, also referred to as atraumatic splenic rupture, is a rare but life-threatening emergency condition. Without timely diagnosis and treatment, the mortality rate of splenic rupture approaches 100%. The etiology of atraumatic splenic rupture varies; it is reportedly associated with neoplasms or splenic infection, but is rarely encountered in patients with both conditions. We herein report the case of a 58-year-old male patient with acute myeloid leukemia (AML) complicated by splenic tuberculosis (TB), who presented with spontaneous rupture of the spleen. Pathological examination of the resected spleen revealed multifocal granulomatosis with caseous necrosis. However, with timely diagnosis and surgical intervention, the patient recovered successfully and is currently on consolidation therapy. To the best of our knowledge, this is the first case of spontaneous splenic rupture in AML with splenic TB. The relevant literature on spontaneous splenic rupture was also reviewed and the potential etiology and treatment were discussed.
自发性脾破裂，也称为非创伤性脾破裂，是一种罕见但危及生命的紧急情况。如果不及时诊断和治疗，脾破裂的死亡率接近100%。非创伤性脾破裂的病因各不相同；据报道，它与肿瘤或脾感染有关，但在同时患有这两种疾病的患者中很少见。我们在此报告一例58岁男性急性髓系白血病（AML）合并脾结核（TB）患者，该患者出现自发性脾破裂。对切除脾脏的病理检查显示多灶性肉芽肿伴干酪样坏死。然而，经过及时诊断和手术干预，患者成功康复，目前正在接受巩固治疗。据我们所知，这是首例AML合并脾结核的自发性脾破裂病例。我们还回顾了自发性脾破裂的相关文献，并讨论了潜在病因和治疗方法。
