Matsumoto Y, Ishiko O, Deguchi M, Ogita S, Haba T, Wakasa K
Department of Obstetrics and Gynecology, Osaka City University Medical School, Abeno-ku, Osaka 545-8585, Japan.
Oncol Rep. 2001 Jan-Feb;8(1):93-7. doi: 10.3892/or.8.1.93.
The purpose of this study was to determine whether intratumor expression of platelet-derived endothelial cell growth factor (PD-ECGF) is a prognostic factor. We examined specimens from 61 cases of carcinoma of uterine cervix (Ca-Cx). Specimens were stained with periodic acid-Schiff preparation with diastase (d-PAS) and alcian blue (pH 2.5) to identify the presence of intracellular mucin. PD-ECGF expression and microvessel count (MVC) were assessed by immunohistochemical staining. Twenty specimens stained positive for mucin. MVC correlated with clinical stage (p<0.01). There was a correlation between PD-ECGF expression and survival time (p<0.05), but no correlation was seen between mucin staining positivity, MVC, and PD-ECGF expression and survival time by the Cox proportional hazard model. Intratumor PD-ECGF expression was not a prognostic factor in keratinizing-type squamous cell carcinoma of the uterine cervix.
本研究的目的是确定肿瘤内血小板衍生内皮细胞生长因子（PD-ECGF）的表达是否为预后因素。我们检查了61例子宫颈癌（Ca-Cx）的标本。标本用淀粉酶消化过碘酸希夫制剂（d-PAS）和阿尔辛蓝（pH 2.5）染色，以识别细胞内粘蛋白的存在。通过免疫组织化学染色评估PD-ECGF表达和微血管计数（MVC）。20个标本粘蛋白染色呈阳性。MVC与临床分期相关（p<0.01）。PD-ECGF表达与生存时间之间存在相关性（p<0.05），但根据Cox比例风险模型，粘蛋白染色阳性、MVC以及PD-ECGF表达与生存时间之间未见相关性。肿瘤内PD-ECGF表达不是子宫颈角化型鳞状细胞癌的预后因素。
