Inoue G, Horiike N, Onji M
Third Department of Internal Medicine, Ehime University School of Medicine, Ehime, Japan.
Int J Mol Med. 2001 Jan;7(1):67-71. doi: 10.3892/ijmm.7.1.67.
The expression of CD81, a cell receptor for hepatitis C virus, was examined on cancer cells in hepatocellular carcinoma (HCC) C (n=29) to clarify its clinical role. CD81 was expressed on hepatocyte membrane in non-tumor portions in all patients, however, this was not stained on the cancer cell membranes in 6 of 29. Reverse transcriptase-PCR revealed that CD81 gene expression was not detected in the tumorous portions in 3 of 7 samples. The loss of CD81 was prominent in poorly differentiated HCC (5 of 8) and extrahepatic metastasis patients (6 of 8). The loss of CD81 is associated with differentiation and metastasis of HCC.
为阐明丙型肝炎病毒细胞受体CD81在肝细胞癌（HCC）C（n = 29）癌细胞中的表达情况，对其临床作用进行了研究。所有患者非肿瘤部位的肝细胞膜均表达CD81，然而，29例中有6例癌细胞膜未被染色。逆转录聚合酶链反应显示，7个样本中有3个肿瘤部位未检测到CD81基因表达。CD81缺失在低分化HCC（8例中的5例）和肝外转移患者（8例中的6例）中尤为明显。CD81缺失与HCC的分化和转移有关。
