Yaseen Ibrahim H, Monk Peter N, Partridge Lynda J
Department of Molecular Biology and Biotechnology, University of Sheffield, Sheffield, U.K.
Department of Infection, Immunity and Cardiovascular Diseases, University of Sheffield Medical School, Sheffield, U.K.
Biochem Soc Trans. 2017 Apr 15;45(2):465-475. doi: 10.1042/BST20160022.
Tetraspanin 2 (Tspan2) is one of the less well-characterised members of the tetraspanin superfamily, and its precise function in different human tissue types remains to be explored. Initial studies have highlighted its possible association in neuroinflammation and carcinogenesis. In the central nervous system, Tspan2 may contribute to the early stages of the oligodendrocyte differentiation into myelin-forming glia. Furthermore, in human lung cancer, Tspan2 could be involved in the progression of the tumour metastasis by modulating cancer cell motility and invasion functions. In this review, we discuss the available evidence for the potential role of Tspan2 and introduce possible strategies for disease targeting.
四跨膜蛋白2（Tspan2）是四跨膜蛋白超家族中特征不太明确的成员之一，其在不同人体组织类型中的精确功能仍有待探索。初步研究突出了其在神经炎症和致癌作用中可能的关联。在中枢神经系统中，Tspan2可能有助于少突胶质细胞分化为形成髓鞘的神经胶质细胞的早期阶段。此外，在人类肺癌中，Tspan2可能通过调节癌细胞的运动性和侵袭功能参与肿瘤转移的进展。在本综述中，我们讨论了关于Tspan2潜在作用的现有证据，并介绍了针对疾病的可能策略。
