Benabarre A, Vieta E, Lomeña F, Martínez-Arán A, Bernardo M, Corbella B, Colom F, Reinares M, Gastó C
Institut Clínic de Psiquiatría i Psicología, Hospital Clínic Universitari, Barcelona.
Actas Esp Psiquiatr. 2000 Jul-Aug;28(4):257-61.
In this review we comment the results of functional neuroimaging works of emotions on normal population and some parallelisms with the emotional changes of bipolar disorder correlated with their functional neuroimaging. Initially we refer the emotional ontogenetical development of human brain based on regional cerebral sanguineous flow evolution (FSC). Secondly we describe the differences of FSC between the externally generated emotions versus internally; between positive versus negative emotions and the correlation between FSC and some facial expressions. When FSC of bipolar disorder is compared with normal emotions on general population, we observe that temporal cortex, the prefrontal medial and insular anterior cortex, change their perfusion with the switch or the change of emotional expression. It is possible to determine if the findings obtained in samples of healthy subjects and bipolar patients converge in a dimensional model, or if on the contrary they support the categorical hypotheses, moving the emotional aspects to a second term on bipolar disorder.
在本综述中，我们评论了关于正常人群情绪的功能性神经影像学研究结果，以及与双相情感障碍情绪变化相关的功能性神经影像学研究中的一些相似之处。首先，我们基于局部脑血流演变（FSC）阐述人类大脑的情绪个体发生发展。其次，我们描述了外部引发的情绪与内部情绪之间、积极情绪与消极情绪之间FSC的差异，以及FSC与一些面部表情之间的相关性。当将双相情感障碍的FSC与普通人群的正常情绪进行比较时，我们观察到颞叶皮质、前额叶内侧皮质和岛叶前皮质会随着情绪表达的转换或变化而改变其灌注。有可能确定在健康受试者和双相情感障碍患者样本中获得的结果是否在一个维度模型中趋同，或者相反，它们是否支持分类假设，从而将情绪方面置于双相情感障碍的次要地位。
