Migliorelli R, Starkstein S E, Tesón A, de Quirós G, Vázquez S, Leiguarda R, Robinson R G
Department of Behavioral Neurology, Raúl Carrea Institute of Neurological Research, Buenos Aires, Argentina.
J Neuropsychiatry Clin Neurosci. 1993 Fall;5(4):379-83. doi: 10.1176/jnp.5.4.379.
Five patients with a manic episode and 7 age-comparable control subjects were studied with single-photon emission computed tomography and [99mTc]d,l-hexamethylpropyleneamine oxime. Manic patients showed significantly lower blood flow in the basal portion of the right temporal lobe compared with normal control subjects. Moreover, manic patients showed a left-right asymmetry (a significantly lower perfusion in the right versus left temporal basal cortex), as well as a dorsal-ventral asymmetry (a significantly lower perfusion in the right temporal basal versus dorsal cortex). These findings suggest that the right basotemporal cortex may play an important role in the production of primary mania.
对5例躁狂发作患者和7名年龄匹配的对照者进行了单光子发射计算机断层扫描和[99mTc]d，l-六甲基丙烯胺肟研究。与正常对照者相比，躁狂患者右侧颞叶底部的血流显著降低。此外，躁狂患者表现出左右不对称（右侧颞叶底部皮质灌注明显低于左侧）以及背腹不对称（右侧颞叶底部皮质灌注明显低于背侧皮质）。这些发现提示右侧颞叶底部皮质可能在原发性躁狂的发生中起重要作用。
