Gómez E, Roncero C, De Pablo J, Rovira M, Mazzarra R, Bladé J, Cirera E
Instituto de Psiquiatría, Sección de Interconsulta Psiquiátrica, Hospital Clínic.
Actas Esp Psiquiatr. 2000 Jul-Aug;28(4):263-6.
The hyperviscosity syndrome has been described clinically as the triad of bleeding, visual signs and neurological manifestations associated with elevated serum viscosity. Several reports have recognised an association between hyperviscosity and altered mental status. Since to our knowledge only a case of hyperviscosity-induced delirium has been described (1), we raise the possibility of this diagnosis in the most of this reported cases, based on the nature of the symptoms, sudden onset and fluctuating course, and its resolution with plasmapheresis. In this paper we review the literature about hyperviscosity syndrome and altered mental status. In conclusion, serum hyperviscosity should be added to the large list of causes altered mental status, especially of delirium. Since plasmapheresis can reverse clinical symptoms, it early recognition and the measurement of serum viscosity is essential in patients suffering from diseases that may lead to this syndrome, and who develop psychiatric symptoms.
高黏滞综合征在临床上被描述为与血清黏度升高相关的出血、视觉症状和神经学表现三联征。多项报告已认识到高黏滞与精神状态改变之间存在关联。据我们所知，仅曾有1例高黏滞所致谵妄的病例被描述，基于这些报告病例中大多数症状的性质、起病急骤和病程波动，以及血浆置换可使其缓解，我们提出了该诊断的可能性。在本文中，我们回顾了有关高黏滞综合征和精神状态改变的文献。总之，血清高黏滞应被列入导致精神状态改变尤其是谵妄的众多病因之中。由于血浆置换可逆转临床症状，对于患有可能导致该综合征且出现精神症状的疾病的患者，早期识别和测定血清黏度至关重要。
