Buzanowski-Konakry K, Harrison E G, Payne W S
Cancer. 1975 Feb;35(2):450-6. doi: 10.1002/1097-0142(197502)35:2<450::aid-cncr2820350223>3.0.co;2-r.
Lobular carcinoma may arise within the epithelial component of fibroadenoma of the breast, as evidenced by 5 cases reported from the files of the Mayo Clinic and 21 cases cited in the literature. The 5 cases reported here occurred in a series of 4000 cases of fibroadenoma during a 43-year period. Lobular carcinoma is the more frequent type to be seen in fibroadenoma (in 22 of 26 cases); it usually develops in situ. Extra-adenomatous carcinoma of the ipsilateral breast was identified in 11 of 26 cases, and 3 cases of contralateral carcinoma were noted in the entire series. Thus, lobular carcinoma arising within the epithelial component of a fibroadenoma has biological features similar to the behavior of lobular carcinoma of the breast in general. The prognosis has been favorable; lesions are usually encountered early; in only 2 of 26 cases were there axillary metastases.
小叶癌可能起源于乳腺纤维腺瘤的上皮成分，梅奥诊所档案报道的5例及文献引用的21例均证明了这一点。这里报道的5例发生在43年期间的4000例纤维腺瘤病例中。小叶癌是纤维腺瘤中较常见的类型（26例中有22例）；它通常原位发生。26例中有11例发现同侧乳腺腺体外癌，整个系列中有3例对侧癌。因此，起源于纤维腺瘤上皮成分的小叶癌具有与一般乳腺小叶癌行为相似的生物学特征。预后良好；病变通常发现较早；26例中只有2例有腋窝转移。
