Zheng Hongmei, Chen Jian, Wu Xinhong, Jin Liting, Qi Chubo
Department of Breast Surgery, Hubei Cancer Hospital, Wuhan, Hubei 430079, P.R. China.
Department of Head and Neck Surgery, Hubei Cancer Hospital, Wuhan, Hubei 430079, P.R. China.
Oncol Lett. 2015 Sep;10(3):1513-1516. doi: 10.3892/ol.2015.3420. Epub 2015 Jun 24.
Fibroadenomas are a type of benign tumor that occur in young women below the age of 35 years old. The tumors are the second most common type of tumor after fibrocystic disease. The chance of carcinoma arising in a fibroadenoma is extremely low. To date, <130 such cases have been reported. Previous studies have reported that fibroadenomas can evolve into a number of different types of malignancy. The present study is the first to describe a case of bilateral primary breast cancer with a unilateral invasive ductal carcinoma within a fibroadenoma. The current study presents a case of a 48-year-old female who presented with 2 stiff lumps on bilateral breasts, diagnosed as bilateral breast carcinoma, with a unilateral invasive ductal carcinoma within a fibroadenoma in the right breast. The patient underwent a bilateral mastectomy and subsequently received 4 cycles of chemotherapy (epirubicin, 60 mg/m and cyclophosphamide, 600 mg/m) every 21 days, followed by 4 cycles of docetaxel chemotherapy (100 mg/m) every 21 days. The patient then received maintenance endocrine therapy (tamoxifen, 20 mg, twice daily) for 19 months. The patient was followed up every 3 months, and at the last follow-up examination in May 2015, the patient exhibited no signs of recurrence.
纤维腺瘤是一种发生在35岁以下年轻女性中的良性肿瘤。这类肿瘤是继纤维囊性疾病之后第二常见的肿瘤类型。纤维腺瘤恶变为癌的几率极低。迄今为止，报道的此类病例不足130例。既往研究报道纤维腺瘤可演变为多种不同类型的恶性肿瘤。本研究首次描述了一例双侧原发性乳腺癌病例，其中一侧乳房的纤维腺瘤内伴有浸润性导管癌。本研究报告了一例48岁女性，其双侧乳房出现2个硬结肿块，诊断为双侧乳腺癌，右侧乳房的纤维腺瘤内伴有浸润性导管癌。该患者接受了双侧乳房切除术，随后每21天接受4个周期的化疗（表柔比星，60 mg/m²和环磷酰胺，600 mg/m²），之后每21天接受4个周期的多西他赛化疗（100 mg/m²）。该患者随后接受了19个月的维持内分泌治疗（他莫昔芬，20 mg，每日两次）。每3个月对患者进行随访，在2015年5月的最后一次随访检查中，患者未表现出复发迹象。
