• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

幽门螺杆菌免疫：白细胞介素-4受体α链状态及感染小鼠性别的意义

Immunity against Helicobacter pylori: significance of interleukin-4 receptor alpha chain status and gender of infected mice.

作者信息

Aebischer T, Laforsch S, Hurwitz R, Brombacher F, Meyer T F

机构信息

Department of Molecular Biology, Max Planck Institute for Infection Biology, 10117 Berlin, Germany.

出版信息

Infect Immun. 2001 Jan;69(1):556-8. doi: 10.1128/IAI.69.1.556-558.2001.

DOI:10.1128/IAI.69.1.556-558.2001
PMID:11119552
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC97918/
Abstract

Vaccination of interleukin-4 (IL-4) receptor alpha (IL-4Ralpha) chain-deficient BALB/c mice with Helicobacter pylori urease and cholera toxin or with urease-expressing, live attenuated Salmonella enterica serovar Typhimurium cells revealed that protection against H. pylori infection is independent of IL-4- or IL-13-mediated signals. A comparison of male and female mice suggests a sexual dimorphism in the extent of bacterial colonization that is particularly evident in the absence of the IL-4Ralpha chain.

摘要

用幽门螺杆菌尿素酶和霍乱毒素或表达尿素酶的减毒活肠炎沙门氏菌血清型鼠伤寒杆菌细胞对白细胞介素-4（IL-4）受体α（IL-4Rα）链缺陷的BALB/c小鼠进行疫苗接种，结果显示，针对幽门螺杆菌感染的保护作用独立于IL-4或IL-13介导的信号。对雄性和雌性小鼠的比较表明，在细菌定植程度上存在性别差异，这在缺乏IL-4Rα链的情况下尤为明显。

相似文献

1
Immunity against Helicobacter pylori: significance of interleukin-4 receptor alpha chain status and gender of infected mice.幽门螺杆菌免疫：白细胞介素-4受体α链状态及感染小鼠性别的意义
Infect Immun. 2001 Jan;69(1):556-8. doi: 10.1128/IAI.69.1.556-558.2001.
2
Adoptive transfer of CD4+ T cells specific for subunit A of Helicobacter pylori urease reduces H. pylori stomach colonization in mice in the absence of interleukin-4 (IL-4)/IL-13 receptor signaling.在缺乏白细胞介素-4（IL-4）/白细胞介素-13受体信号传导的情况下，采用针对幽门螺杆菌脲酶亚基A的CD4 + T细胞进行过继转移可减少小鼠胃中幽门螺杆菌的定植。
Infect Immun. 2001 Mar;69(3):1714-21. doi: 10.1128/IAI.69.3.1714-1721.2001.
3
Oral vaccination with liposome-encapsulated recombinant fusion peptide of urease B epitope and cholera toxin B subunit affords prophylactic and therapeutic effects against H. pylori infection in BALB/c mice.用脂质体包裹的脲酶B表位和霍乱毒素B亚基的重组融合肽进行口服疫苗接种，对BALB/c小鼠的幽门螺杆菌感染具有预防和治疗作用。
Vaccine. 2007 Nov 1;25(44):7664-73. doi: 10.1016/j.vaccine.2007.08.034. Epub 2007 Sep 5.
4
Prophylactic and therapeutic efficacy of the epitope vaccine CTB-UA against Helicobacter pylori infection in a BALB/c mice model.CTB-UA 表位疫苗对 BALB/c 小鼠幽门螺杆菌感染的预防和治疗效果。
Appl Microbiol Biotechnol. 2012 Sep;95(6):1437-44. doi: 10.1007/s00253-012-4122-0. Epub 2012 May 10.
5
gammadelta T cells increase with gastric mucosal interleukin (IL)-7, IL-1beta, and Helicobacter pylori urease specific immunoglobulin levels via CCR2 upregulation in Helicobacter pylori gastritis.在幽门螺杆菌胃炎中，γδ T细胞通过CCR2上调，随胃黏膜白细胞介素（IL）-7、IL-1β和幽门螺杆菌脲酶特异性免疫球蛋白水平升高而增加。
J Gastroenterol Hepatol. 2006 Jan;21(1 Pt 1):32-40. doi: 10.1111/j.1440-1746.2005.04148.x.
6
Mucosal vaccination increases local chemokine production attracting immune cells to the stomach mucosa of Helicobacter pylori infected mice.黏膜疫苗接种会增加局部趋化因子的产生，吸引免疫细胞进入幽门螺杆菌感染小鼠的胃黏膜。
Vaccine. 2012 Feb 21;30(9):1636-43. doi: 10.1016/j.vaccine.2011.12.111. Epub 2012 Jan 9.
7
Protection Against Infection in BALB/c Mouse Model by Oral Administration of Multivalent Epitope-Based Vaccine of Cholera Toxin B Subunit-HUUC.口服基于多价表位的霍乱毒素 B 亚单位-HUUC 疫苗对 BALB/c 小鼠模型的抗感染保护作用。
Front Immunol. 2018 May 8;9:1003. doi: 10.3389/fimmu.2018.01003. eCollection 2018.
8
Oral immunization of mice with attenuated Salmonella typhimurium expressing Helicobacter pylori urease B subunit.用表达幽门螺杆菌脲酶B亚基的减毒鼠伤寒沙门氏菌对小鼠进行口服免疫。
Chin Med J (Engl). 2002 Oct;115(10):1513-6.
9
Mucosal immunization with a urease B DNA vaccine induces innate and cellular immune responses against Helicobacter pylori.用尿素酶B DNA疫苗进行黏膜免疫可诱导针对幽门螺杆菌的固有免疫和细胞免疫反应。
Helicobacter. 2006 Apr;11(2):113-22. doi: 10.1111/j.1523-5378.2006.00385.x.
10
Interleukin-17 is a critical mediator of vaccine-induced reduction of Helicobacter infection in the mouse model.白细胞介素-17是小鼠模型中疫苗诱导的幽门螺杆菌感染减少的关键介质。
Gastroenterology. 2009 Jun;136(7):2237-2246.e1. doi: 10.1053/j.gastro.2009.02.077. Epub 2009 Mar 9.

引用本文的文献

1
Recombinant Vaccine Delivery Vehicle: A Promising Tool to Treat Infections and Combat Antimicrobial Resistance.重组疫苗递送载体：治疗感染和对抗抗菌药物耐药性的一种有前景的工具。
Antibiotics (Basel). 2022 Nov 25;11(12):1701. doi: 10.3390/antibiotics11121701.
2
GM-CSF is key in the efficacy of vaccine-induced reduction of Helicobacter pylori infection.GM-CSF 是疫苗诱导减少幽门螺杆菌感染疗效的关键。
Helicobacter. 2022 Apr;27(2):e12875. doi: 10.1111/hel.12875. Epub 2022 Jan 29.
3
Interleukin-21 (IL-21) Downregulates Dendritic Cell Cytokine Responses to Helicobacter pylori and Modulates T Lymphocyte IL-17A Expression in Peyer's Patches during Infection.白细胞介素-21（IL-21）下调树突状细胞对幽门螺杆菌的细胞因子反应，并在感染期间调节派尔集合淋巴结中 T 淋巴细胞的白细胞介素-17A 表达。
Infect Immun. 2019 Oct 18;87(11). doi: 10.1128/IAI.00237-19. Print 2019 Nov.
4
When the balance is broken: X-linked gene dosage from two X chromosomes and female-biased autoimmunity.当平衡被打破时：来自两条 X 染色体的 X 连锁基因剂量与女性偏向性自身免疫。
J Leukoc Biol. 2019 Oct;106(4):919-932. doi: 10.1002/JLB.6RI0319-094R. Epub 2019 May 24.
5
Strategies used by to establish persistent infection.宿主建立持续性感染所使用的策略。
World J Gastroenterol. 2017 Apr 28;23(16):2870-2882. doi: 10.3748/wjg.v23.i16.2870.
6
Host Determinants of Expression of the Helicobacter pylori BabA Adhesin.幽门螺杆菌 BabA 黏附素表达的宿主决定因素。
Sci Rep. 2017 Apr 18;7:46499. doi: 10.1038/srep46499.
7
Role of Inflammatory Monocytes in Vaccine-Induced Reduction of Helicobacter felis Infection.炎症单核细胞在疫苗诱导减少幽门螺杆菌感染中的作用。
Infect Immun. 2015 Nov;83(11):4217-28. doi: 10.1128/IAI.01026-15. Epub 2015 Aug 17.
8
Immune responses to Helicobacter pylori infection.对幽门螺杆菌感染的免疫反应。
World J Gastroenterol. 2014 May 21;20(19):5583-93. doi: 10.3748/wjg.v20.i19.5583.
9
Vaccinating against Helicobacter pylori in the developing world.在发展中国家接种幽门螺杆菌疫苗。
Gut Microbes. 2013 Nov-Dec;4(6):568-76. doi: 10.4161/gmic.27093. Epub 2013 Nov 6.
10
Serum Helicobacter pylori CagA antibody titer as a useful marker for advanced inflammation in the stomach in Japan.血清幽门螺杆菌 CagA 抗体滴度可作为日本胃部中重度炎症的有用标志物。
J Gastroenterol Hepatol. 2014 Jan;29(1):67-73. doi: 10.1111/jgh.12359.

本文引用的文献

1
Therapeutic oral vaccination induces mucosal immune response sufficient to eliminate long-term Helicobacter pylori infection.
Microbiol Immunol. 2000;44(1):29-39. doi: 10.1111/j.1348-0421.2000.tb01243.x.
2
Helicobacter pylori infection in interleukin-4-deficient and transgenic mice.白细胞介素-4缺陷型和转基因小鼠中的幽门螺杆菌感染
Scand J Gastroenterol. 1999 Oct;34(10):987-92. doi: 10.1080/003655299750025084.
3
Naturally acquired human immune responses against Helicobacter pylori and implications for vaccine development.人类针对幽门螺杆菌的自然获得性免疫反应及其对疫苗研发的意义。
Gut. 1999 Sep;45(3):465-74. doi: 10.1136/gut.45.3.465.
4
Differences between IL-4- and IL-4 receptor alpha-deficient mice in chronic leishmaniasis reveal a protective role for IL-13 receptor signaling.白细胞介素-4及白细胞介素-4受体α缺陷小鼠在慢性利什曼病中的差异揭示了白细胞介素-13受体信号传导的保护作用。
J Immunol. 1999 Jun 15;162(12):7302-8.
5
Helicobacter pylori infection in immunized mice lacking major histocompatibility complex class I and class II functions.缺乏主要组织相容性复合体I类和II类功能的免疫小鼠中的幽门螺杆菌感染
Infect Immun. 1999 Jan;67(1):337-41. doi: 10.1128/IAI.67.1.337-341.1999.
6
Role of gamma interferon in Helicobacter pylori-induced gastric inflammatory responses in a mouse model.γ干扰素在小鼠模型中幽门螺杆菌诱导的胃炎症反应中的作用
Infect Immun. 1999 Jan;67(1):279-85. doi: 10.1128/IAI.67.1.279-285.1999.
7
Immunization of mice with urease vaccine affords protection against Helicobacter pylori infection in the absence of antibodies and is mediated by MHC class II-restricted responses.用脲酶疫苗免疫小鼠可在无抗体的情况下提供针对幽门螺杆菌感染的保护，且由MHC II类限制性反应介导。
J Exp Med. 1998 Dec 21;188(12):2277-88. doi: 10.1084/jem.188.12.2277.
8
Antrum- and corpus mucosa-infiltrating CD4(+) lymphocytes in Helicobacter pylori gastritis display a Th1 phenotype.幽门螺杆菌胃炎中胃窦和胃体黏膜浸润的CD4(+)淋巴细胞表现出Th1表型。
Infect Immun. 1998 Nov;66(11):5543-6. doi: 10.1128/IAI.66.11.5543-5546.1998.
9
Immunization of BALB/c mice with Helicobacter urease B induces a T helper 2 response absent in Helicobacter infection.用幽门螺杆菌尿素酶B免疫BALB/c小鼠可诱导出幽门螺杆菌感染中不存在的辅助性T细胞2型反应。
Gastroenterology. 1998 Oct;115(4):891-7. doi: 10.1016/s0016-5085(98)70261-6.
10
Vaccine development against infection with Helicobacter pylori.
Br Med Bull. 1998;54(1):229-41. doi: 10.1093/oxfordjournals.bmb.a011673.