幽门螺杆菌胃炎中胃窦和胃体黏膜浸润的CD4(+)淋巴细胞表现出Th1表型。
Antrum- and corpus mucosa-infiltrating CD4(+) lymphocytes in Helicobacter pylori gastritis display a Th1 phenotype.
作者信息
Sommer F, Faller G, Konturek P, Kirchner T, Hahn E G, Zeus J, Röllinghoff M, Lohoff M
机构信息
Institut für Klinische Mikrobiologie, Immunologie und Hygiene der Universität Erlangen-Nürnberg, Erlangen, Germany.
出版信息
Infect Immun. 1998 Nov;66(11):5543-6. doi: 10.1128/IAI.66.11.5543-5546.1998.
Abstract
In this study, cytokine patterns produced by CD4(+) T cells isolated from antrum or corpus gastral biopsy specimens of 10 patients with Helicobacter pylori-positive gastritis were compared. To this end, expression of intracellular cytokines (interleukin-4 [IL-4] and gamma interferon) and of CD4 was assessed by flow cytometry. Ten to 60% of the isolated CD4(+) T cells produced gamma interferon upon stimulation. With the exception of one patient, IL-4-positive CD4(+) cells were not detected. Therefore, CD4(+) cells infiltrating antrum and corpus stomach mucosa during H. pylori infection show a Th1 phenotype. This polarized Th1-type response may contribute to the inability of the immune system to eradicate H. pylori infection.
摘要
在本研究中，比较了从10例幽门螺杆菌阳性胃炎患者的胃窦或胃体活检标本中分离出的CD4(+) T细胞产生的细胞因子模式。为此，通过流式细胞术评估细胞内细胞因子（白细胞介素-4 [IL-4]和γ干扰素）及CD4的表达。10%至60%的分离出的CD4(+) T细胞在受到刺激后产生γ干扰素。除1例患者外，未检测到IL-4阳性的CD4(+)细胞。因此，幽门螺杆菌感染期间浸润胃窦和胃体黏膜的CD4(+)细胞表现出Th1表型。这种极化的Th1型反应可能导致免疫系统无法根除幽门螺杆菌感染。
相似文献
1
Antrum- and corpus mucosa-infiltrating CD4(+) lymphocytes in Helicobacter pylori gastritis display a Th1 phenotype.幽门螺杆菌胃炎中胃窦和胃体黏膜浸润的CD4(+)淋巴细胞表现出Th1表型。
Infect Immun. 1998 Nov;66(11):5543-6. doi: 10.1128/IAI.66.11.5543-5546.1998.
2
3
Recruitment of CCR6 Foxp3 regulatory gastric infiltrating lymphocytes in Helicobacter pylori gastritis.招募 CCR6 Foxp3 调节性胃浸润淋巴细胞在幽门螺杆菌胃炎中的作用。
Helicobacter. 2019 Feb;24(1):e12550. doi: 10.1111/hel.12550. Epub 2018 Nov 9.
4
Downregulated regulatory T cell function is associated with increased peptic ulcer in Helicobacter pylori-infection.调节性T细胞功能下调与幽门螺杆菌感染中消化性溃疡的增加有关。
Microb Pathog. 2017 Sep;110:165-175. doi: 10.1016/j.micpath.2017.06.040. Epub 2017 Jun 27.
5
[CD4+ and CD8+ T cells in gastric mucosa in children infected with Helicobacter pylori].幽门螺杆菌感染儿童胃黏膜中的CD4+和CD8+ T细胞
Zhonghua Er Ke Za Zhi. 2005 Jun;43(6):453-6.
6
7
Correlation between CD4, CD8 cell infiltration in gastric mucosa, Helicobacter pylori infection and symptoms in patients with chronic gastritis.慢性胃炎患者胃黏膜中CD4、CD8细胞浸润、幽门螺杆菌感染与症状之间的相关性
World J Gastroenterol. 2005 Apr 28;11(16):2486-90. doi: 10.3748/wjg.v11.i16.2486.
8
Interferon gamma and interleukin 4 secreting cells in the gastric antrum in Helicobacter pylori positive and negative gastritis.幽门螺杆菌阳性和阴性胃炎患者胃窦中分泌γ干扰素和白细胞介素4的细胞
Gut. 1995 Mar;36(3):341-5. doi: 10.1136/gut.36.3.341.
9
Synergistic effect of IL-1β and TNF-α polymorphisms on the H. pylori-related gastric pre-malignant condition.白细胞介素-1β和肿瘤坏死因子-α基因多态性对幽门螺杆菌相关胃癌前病变的协同作用。
Hepatogastroenterology. 2012 Nov-Dec;59(120):2416-20. doi: 10.5754/hge10605.
10
Increased Indoleamine 2, 3-Dioxygenase expression modulates Th1/Th17/Th22 and Treg pathway in humans with Helicobacter Pylori-Infected gastric mucosa.幽门螺杆菌感染胃黏膜中吲哚胺 2,3-双加氧酶表达增加调节 Th1/Th17/Th22 和 Treg 途径。
Hum Immunol. 2021 Jan;82(1):46-53. doi: 10.1016/j.humimm.2020.10.005. Epub 2020 Oct 28.
引用本文的文献
1
The Importance of Th2 Immune Responses in Mediating the Progression of Gastritis-Associated Metaplasia to Gastric Cancer.Th2免疫反应在介导胃炎相关化生进展为胃癌过程中的重要性。
Cancers (Basel). 2024 Jan 25;16(3):522. doi: 10.3390/cancers16030522.
2
Antagonistic and Immunomodulant Effects of Two Probiotic Strains of Lactobacillus on Clinical Strains of .两种乳酸杆菌益生菌菌株对……临床菌株的拮抗和免疫调节作用
Galen Med J. 2020 Oct 14;9:e1794. doi: 10.31661/gmj.v9i0.1794. eCollection 2020.
3
Isolation of lymphocytes from the human gastric mucosa.从人胃黏膜中分离淋巴细胞。
World J Methodol. 2021 Jul 20;11(4):199-207. doi: 10.5662/wjm.v11.i4.199.
4
Eradication of and Gastric Cancer: A Controversial Relationship.幽门螺杆菌与胃癌：一种存在争议的关系。
Front Microbiol. 2021 Feb 4;12:630852. doi: 10.3389/fmicb.2021.630852. eCollection 2021.
5
Analysis of Correlation between the Seven Important (. ) Virulence Factors and Drug Resistance in Patients with Gastritis.胃炎患者七种重要（.）毒力因子与耐药性的相关性分析
Gastroenterol Res Pract. 2020 Aug 29;2020:3956838. doi: 10.1155/2020/3956838. eCollection 2020.
6
in human health and disease: Mechanisms for local gastric and systemic effects.在人类健康和疾病中的作用：局部胃和全身效应的机制。
World J Gastroenterol. 2018 Jul 28;24(28):3071-3089. doi: 10.3748/wjg.v24.i28.3071.
7
Mediated Protection against Extra-Gastric Immune and Inflammatory Disorders: The Evidence and Controversies.介导的针对胃外免疫和炎症性疾病的保护作用：证据与争议
Diseases. 2015 Mar 27;3(2):34-55. doi: 10.3390/diseases3020034.
8
, Hygiene, Atopy, and Asthma.卫生、特应性和哮喘。
Front Microbiol. 2017 Jun 8;8:1034. doi: 10.3389/fmicb.2017.01034. eCollection 2017.
9
A Gain-Of-Function Mutation in the Plcg2 Gene Protects Mice from Helicobacter felis-Induced Gastric MALT Lymphoma.Plcg2 基因的功能获得性突变可保护小鼠免受幽门螺杆菌感染引起的胃黏膜相关淋巴组织淋巴瘤。
PLoS One. 2016 Mar 11;11(3):e0150411. doi: 10.1371/journal.pone.0150411. eCollection 2016.
10
IL-17a and IL-22 Induce Expression of Antimicrobials in Gastrointestinal Epithelial Cells and May Contribute to Epithelial Cell Defense against Helicobacter pylori.IL-17a 和 IL-22 诱导胃肠道上皮细胞表达抗菌肽，可能有助于上皮细胞抵抗幽门螺杆菌。
PLoS One. 2016 Feb 11;11(2):e0148514. doi: 10.1371/journal.pone.0148514. eCollection 2016.
本文引用的文献
1
The effect of class II major histocompatibility complex expression on adherence of Helicobacter pylori and induction of apoptosis in gastric epithelial cells: a mechanism for T helper cell type 1-mediated damage.II类主要组织相容性复合体表达对幽门螺杆菌黏附及胃上皮细胞凋亡诱导的影响：1型辅助性T细胞介导损伤的一种机制
J Exp Med. 1998 May 18;187(10):1659-69. doi: 10.1084/jem.187.10.1659.
2
Lymphocytes in the human gastric mucosa during Helicobacter pylori have a T helper cell 1 phenotype.幽门螺杆菌感染时，人胃黏膜中的淋巴细胞具有辅助性T细胞1表型。
Gastroenterology. 1998 Mar;114(3):482-92. doi: 10.1016/s0016-5085(98)70531-1.
3
Antigastric autoantibodies in Helicobacter pylori infection: implications of histological and clinical parameters of gastritis.幽门螺杆菌感染中的抗胃自身抗体：胃炎组织学和临床参数的意义
Gut. 1997 Nov;41(5):619-23. doi: 10.1136/gut.41.5.619.
4
Murine CD4 T-cell response to Helicobacter infection: TH1 cells enhance gastritis and TH2 cells reduce bacterial load.小鼠CD4 T细胞对幽门螺杆菌感染的反应：TH1细胞加剧胃炎，而TH2细胞降低细菌载量。
Gastroenterology. 1997 Dec;113(6):1848-57. doi: 10.1016/s0016-5085(97)70004-0.
5
Differential stimulation of interleukin-12 (IL-12) and IL-10 by live and killed Helicobacter pylori in vitro and association of IL-12 production with gamma interferon-producing T cells in the human gastric mucosa.活的和灭活的幽门螺杆菌在体外对白细胞介素-12（IL-12）和IL-10的差异刺激以及人胃黏膜中IL-12产生与产生γ干扰素的T细胞的关联
Infect Immun. 1997 Oct;65(10):4229-35. doi: 10.1128/iai.65.10.4229-4235.1997.
6
Different cytokine profile and antigen-specificity repertoire in Helicobacter pylori-specific T cell clones from the antrum of chronic gastritis patients with or without peptic ulcer.患有或不患有消化性溃疡的慢性胃炎患者胃窦部幽门螺杆菌特异性T细胞克隆中不同的细胞因子谱和抗原特异性库。
Eur J Immunol. 1997 Jul;27(7):1751-5. doi: 10.1002/eji.1830270723.
7
Molecular mimicry between Helicobacter pylori and the host.幽门螺杆菌与宿主之间的分子模拟
Trends Microbiol. 1997 Feb;5(2):70-3. doi: 10.1016/S0966-842X(96)10084-6.
8
Expression of mRNA for interferon-gamma, interleukin-10, and interleukin-12 (p40) in normal gastric mucosa and in mucosa infected with Helicobacter pylori.正常胃黏膜及幽门螺杆菌感染黏膜中γ-干扰素、白细胞介素-10和白细胞介素-12（p40）的mRNA表达
Scand J Gastroenterol. 1997 Jan;32(1):22-7. doi: 10.3109/00365529709025058.
9
T helper 1 effector cells specific for Helicobacter pylori in the gastric antrum of patients with peptic ulcer disease.消化性溃疡病患者胃窦中针对幽门螺杆菌的辅助性T1效应细胞。
J Immunol. 1997 Jan 15;158(2):962-7.
10
Antigenic mimicry between Helicobacter pylori and gastric mucosa in the pathogenesis of body atrophic gastritis.幽门螺杆菌与胃黏膜之间的抗原模拟在胃体萎缩性胃炎发病机制中的作用
Gastroenterology. 1996 Sep;111(3):655-65. doi: 10.1053/gast.1996.v111.pm8780570.
Zotero 插件