幽门螺杆菌胃炎中胃窦和胃体黏膜浸润的CD4(+)淋巴细胞表现出Th1表型。
Antrum- and corpus mucosa-infiltrating CD4(+) lymphocytes in Helicobacter pylori gastritis display a Th1 phenotype.
作者信息
Sommer F, Faller G, Konturek P, Kirchner T, Hahn E G, Zeus J, Röllinghoff M, Lohoff M
机构信息
Institut für Klinische Mikrobiologie, Immunologie und Hygiene der Universität Erlangen-Nürnberg, Erlangen, Germany.
出版信息
Infect Immun. 1998 Nov;66(11):5543-6. doi: 10.1128/IAI.66.11.5543-5546.1998.
Abstract
In this study, cytokine patterns produced by CD4(+) T cells isolated from antrum or corpus gastral biopsy specimens of 10 patients with Helicobacter pylori-positive gastritis were compared. To this end, expression of intracellular cytokines (interleukin-4 [IL-4] and gamma interferon) and of CD4 was assessed by flow cytometry. Ten to 60% of the isolated CD4(+) T cells produced gamma interferon upon stimulation. With the exception of one patient, IL-4-positive CD4(+) cells were not detected. Therefore, CD4(+) cells infiltrating antrum and corpus stomach mucosa during H. pylori infection show a Th1 phenotype. This polarized Th1-type response may contribute to the inability of the immune system to eradicate H. pylori infection.
摘要
在本研究中，比较了从10例幽门螺杆菌阳性胃炎患者的胃窦或胃体活检标本中分离出的CD4(+) T细胞产生的细胞因子模式。为此，通过流式细胞术评估细胞内细胞因子（白细胞介素-4 [IL-4]和γ干扰素）及CD4的表达。10%至60%的分离出的CD4(+) T细胞在受到刺激后产生γ干扰素。除1例患者外，未检测到IL-4阳性的CD4(+)细胞。因此，幽门螺杆菌感染期间浸润胃窦和胃体黏膜的CD4(+)细胞表现出Th1表型。这种极化的Th1型反应可能导致免疫系统无法根除幽门螺杆菌感染。
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