Martens A, De Moor A, Demeulemeester J, Ducatelle R
Department of Large Animal Surgery and Anaesthesiology, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820 Merelbeke, Belgium.
Res Vet Sci. 2000 Dec;69(3):295-300. doi: 10.1053/rvsc.2000.0432.
The purpose of this study was to determine the characteristics of occult, verrucous, fibroblastic, nodular and mixed equine sarcoids. Ten tumours of each type were examined histologically and analysed for the presence of bovine papilloma virus (BPV)- DNA. All tumours were positive for BPV - DNA and showed an increased density of dermal fibroblasts. Epidermal hyperplasia, hyperkeratosis, rete peg and 'picket fence' formation were only found consistently in the verrucous and mixed types and were often not present in occult and nodular sarcoids. Immunohistochemical staining for Keratins 10 and 16, Ki67 and p53 showed no important differences between the clinical types. It can be concluded that the presence of BPV - DNA and the increased density of dermal fibroblasts were the only common characteristics for all sarcoids of the different clinical types. The presence of other microscopic alterations was variable but could not be used in the differentiation of the clinical types based on histology.
本研究的目的是确定隐匿型、疣状、纤维母细胞型、结节型和混合型马肉瘤的特征。对每种类型的10个肿瘤进行组织学检查，并分析牛乳头瘤病毒（BPV）-DNA的存在情况。所有肿瘤的BPV-DNA均呈阳性，且真皮成纤维细胞密度增加。表皮增生、角化过度、 rete钉突和“栅栏”状结构仅在疣状和混合型中持续出现，而在隐匿型和结节型肉瘤中通常不存在。角蛋白10和16、Ki67和p53的免疫组织化学染色在不同临床类型之间未显示出重要差异。可以得出结论，BPV-DNA的存在和真皮成纤维细胞密度增加是所有不同临床类型肉瘤的唯一共同特征。其他微观改变的存在是可变的，但不能用于基于组织学对临床类型进行鉴别。
