Wirbelauer C, Scholz C, Hoerauf H, Engelhardt R, Birngruber R, Laqua H
Augenklinik der Medizinischen Universität zu Lübeck (Drs Wirbelauer, Hoerauf, and Laqua), Lübeck, Germany.
Am J Ophthalmol. 2000 Dec;130(6):693-9. doi: 10.1016/s0002-9394(00)00602-4.
To investigate the representation of the corneal structure with optical coherence tomography before and immediately after excimer laser photorefractive keratectomy.
Twenty-four eyes of 24 patients with myopia and myopic astigmatism were prospectively studied. The corneal thickness and the corneal profile were assessed with slit-lamp-adapted optical coherence tomography preoperatively and immediately after excimer laser photorefractive keratectomy.
The attempted mean spherical equivalent of the refractive corrections was -6.7 +/- 3.6 (mean +/- SD) diopters with a mean calculated stromal ablation depth of 91 +/- 38 microm. The corneal optical coherence tomography was reproducible in all patients, demonstrating a mean decrease of central corneal thickness after epithelial debridement and excimer laser photorefractive keratectomy of 118 +/- 45 microm. The comparison of the calculated stromal ablation depth and the corneal thickness changes determined by corneal optical coherence tomography revealed a significant linear relationship with a correlation coefficient of 0.88 (P <.001). The flattening of the corneal curvature was confirmed in all patients with the optical coherence tomography system and correlated with the attempted refractive correction (r =.82, P <.001).
The slit-lamp-adapted optical coherence tomography system presented in this study allowed noncontact, cross-sectional, and high-resolution imaging of the corneal configuration. This initial clinical evaluation demonstrated that corneal optical coherence tomography could be a promising diagnostic modality to monitor corneal changes of thickness and curvature before and after excimer laser photorefractive keratectomy.
研究准分子激光屈光性角膜切削术（PRK）术前及术后即刻角膜结构在光学相干断层扫描（OCT）下的表现。
对24例近视及近视散光患者的24只眼进行前瞻性研究。术前及PRK术后即刻采用适配裂隙灯的光学相干断层扫描评估角膜厚度及角膜轮廓。
屈光矫正的预期平均等效球镜度为-6.7±3.6（均值±标准差）屈光度，计算得到的平均基质消融深度为91±38微米。所有患者的角膜光学相干断层扫描结果均可重复，显示上皮清创及PRK术后中央角膜厚度平均减少118±45微米。计算得到的基质消融深度与角膜光学相干断层扫描测定的角膜厚度变化的比较显示，二者存在显著的线性关系，相关系数为0.88（P<.001）。光学相干断层扫描系统证实所有患者角膜曲率均变平，且与预期屈光矫正相关（r=.82，P<.001）。
本研究中介绍的适配裂隙灯的光学相干断层扫描系统可对角膜形态进行非接触、横断面及高分辨率成像。这一初步临床评估表明，角膜光学相干断层扫描可能是一种有前景的诊断方法，可用于监测PRK术前及术后角膜厚度和曲率的变化。
