使用眼前节光学相干断层扫描术与超声测厚法对中央角膜厚度进行比较。
Comparison of Central Corneal Thickness using Anterior Segment Optical Coherence Tomography Versus Ultrasound Pachymetry.
作者信息
Ramesh Prasanna Venkatesh, Jha Kirti Nath, Srikanth Krishnagopal
机构信息
Senior Resident, Department of Ophthalmology, Mahatma Gandhi Medical College and Research Institute, Sri Balaji Vidyapeeth University, Puducherry, India.
Professor, Department of Ophthalmology, Mahatma Gandhi Medical College and Research Institute, Sri Balaji Vidyapeeth University, Puducherry, India.
出版信息
J Clin Diagn Res. 2017 Aug;11(8):NC08-NC11. doi: 10.7860/JCDR/2017/25595.10420. Epub 2017 Aug 1.
INTRODUCTION
Corneal thickness is an important and sensitive indicator of corneal health. It is useful in monitoring corneal diseases such as corneal oedema and keratoconus, and selecting patients for refractive surgery. Central Corneal Thickness (CCT) is a risk factor for Primary Open-Angle Glaucoma (POAG).
AIM
To compare CCT using ultrasound pachymetry and Anterior Segment Optical Coherence Tomography (AS-OCT), and also to find out the reproducibility of AS-OCT readings for both central and pericentral corneal areas.
MATERIALS AND METHODS
This prospective cross-sectional study was conducted on 120 patients above 40 years of age, and with clinically normal corneas, who underwent CCT measurements by both ultrasound and AS-OCT. Both the eyes were analysed. Two measurements by AS-OCT and 25 measurements by ultrasound pachymetry were taken. The readings were averaged and compared by paired t-test. Repeatability of the OCT pachymetry map sector averages, was assessed by pooled standard deviation, obtained from the two measurements taken from each eye.
RESULTS
The CCT in right eye by OCT and ultrasound was 516.28±29.76 µm and 532.42±29.71 µm, respectively. The CCT in left eye by OCT and ultrasound was 515.82±29.88 µm and 532.36±29.83 µm, respectively. The difference in CCT measurement by AS-OCT and ultrasound was statistically significant (p<0.001); mean ultrasound CCT being 16.14 µm and 16.54 µm greater than the mean AS-OCT, CCT in right eye and left eye respectively. For AS-OCT, intra-session repeatability was measured. Repeatability of the OCT mapping was 0.01 µm to 1.6 µm and 0.01 µm to 1.9 µm in the right eye and left eye respectively.
CONCLUSION
The CCT measurement by ultrasound pachymetry gives higher values compared to AS-OCT measurement. Hence, they cannot be interchangeably used in clinical practice. The AS-OCT provides highly repeatable pachymetry map measurements both centrally and pericentrally.
引言
角膜厚度是角膜健康的一个重要且敏感的指标。它在监测诸如角膜水肿和圆锥角膜等角膜疾病以及为屈光手术选择患者方面很有用。中央角膜厚度（CCT）是原发性开角型青光眼（POAG）的一个危险因素。
目的
比较使用超声测厚法和眼前节光学相干断层扫描（AS - OCT）测量的CCT，并找出AS - OCT在中央和周边角膜区域读数的可重复性。
材料与方法
这项前瞻性横断面研究针对120名40岁以上且角膜临床正常的患者进行，这些患者同时接受了超声和AS - OCT的CCT测量。对双眼进行分析。AS - OCT进行了两次测量，超声测厚法进行了25次测量。对读数取平均值并通过配对t检验进行比较。通过从每只眼睛的两次测量中获得的合并标准差评估OCT测厚图扇区平均值的重复性。
结果
OCT测量右眼的CCT为516.28±29.76 µm，超声测量为532.42±29.71 µm。OCT测量左眼的CCT为515.82±29.88 µm，超声测量为532.36±29.83 µm。AS - OCT和超声测量CCT的差异具有统计学意义（p<0.001）；超声测量的平均CCT在右眼和左眼分别比AS - OCT测量的平均CCT大16.14 µm和16.54 µm。对于AS - OCT，测量了测量期间的可重复性。OCT测量图在右眼和左眼的重复性分别为0.01 µm至1.6 µm和0.01 µm至1.9 µm。
结论
与AS - OCT测量相比，超声测厚法测量的CCT值更高。因此，在临床实践中它们不能互换使用。AS - OCT在中央和周边区域均提供高度可重复的测厚图测量。
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