Mejía-Aranguré J M, Fajardo-Gutiérrez A, Bernáldez-Ríos R, Paredes-Aguilera R, Flores-Aguilar H, Martínez-García M C
Unidad de Investigación Médica en Epidemiología Clínica, Hospital de Pediatría, Centro Médico Nacional Siglo XXI (CMN SXXI), Instituto Mexicano del Seguro Social, (IMSS), México.
Salud Publica Mex. 2000 Sep-Oct;42(5):431-7.
To measure the incidence rate and trend of acute leukemia (AL) in political districts of Mexico City.
Descriptive longitudinal study conducted at six hospitals that care for nearly 97.5% of all cancer cases among children in Mexico City. Study data were collected in 1995 and 1996, and were analyzed in 1999, at the National Medical Center "Siglo XXI" Children's Hospital, of the Mexican Institute for Social Security. Calculations of acute leukemia annual incidence rates, standardized rates, and standardized morbidity rates (SMR) with 95% confidence intervals, were obtained for each district. Morbidity trends were assessed through average change rates.
In this study we observed an increasing trend of acute lymphoblastic leukemia (ALL) incidence in five districts: Alvaro Obregon, Cuauhtemoc, Gustavo A. Madero, Iztacalco, and Venustiano Carranza. Acute myeloblastic leukemia (AML) showed no significantly statistic increase of incidence in any district. AML did show a significant SMR in Alvaro Obregon district (SMR = 2.91, 95% CI 1.63-4.80). Higher SMRs were found in the south and southwest areas of the city.
Increasing incidence of ALL was observed in five districts of Mexico City. AML incidence was the highest in Alvaro Obregon district.
测定墨西哥城各行政区急性白血病（AL）的发病率及变化趋势。
在墨西哥城六家诊治几乎所有儿童癌症病例（占比97.5%）的医院开展描述性纵向研究。研究数据于1995年和1996年收集，并于1999年在墨西哥社会保障局国立医学中心“二十一世纪”儿童医院进行分析。计算每个行政区急性白血病的年发病率、标准化发病率及标准化发病比（SMR），并给出95%置信区间。通过平均变化率评估发病趋势。
在本研究中，我们观察到阿尔瓦罗·奥夫雷贡、库奥赫特莫克、古斯塔沃·A·马德罗、伊萨卡尔科和贝努斯蒂亚诺·卡兰萨这五个行政区的急性淋巴细胞白血病（ALL）发病率呈上升趋势。在任何行政区，急性髓细胞白血病（AML）的发病率均未显示出显著的统计学上升。在阿尔瓦罗·奥夫雷贡区，AML的标准化发病比显著升高（SMR = 2.91，95%置信区间1.63 - 4.80）。在该市的南部和西南部地区发现了更高的标准化发病比。
墨西哥城五个行政区的ALL发病率呈上升趋势。阿尔瓦罗·奥夫雷贡区的AML发病率最高。
