Sakka S G, Reinhart K, Meier-Hellmann A
Department of Anesthesiology and Intensive Care Medicine, Friedrich Schiller University of Jena, Germany.
Intensive Care Med. 2000 Oct;26(10):1553-6. doi: 10.1007/s001340000639.
We studied the correlation between invasive (aortic fiberoptic) and noninvasive (transcutaneous sensor) measurements of indocyanine green (ICG) plasma disappearance rate (PDR) in critically ill patients.
Prospective clinical study in a surgical intensive care unit of a university hospital.
16 critically ill patients with adult respiratory distress syndrome (n = 8), sepsis/septic shock (n = 6), subarachnoid hemorrhage (n = 1), or severe head injury (n = 1).
We analyzed 16 pairs of simultaneous ICG PDR measurements. All patients were deeply sedated and mechanically ventilated. Each patient received a 4-F aortic catheter with an integrated fiberoptic and thermistor connected to a computer system for automatic calculation of invasive ICG PDR (PDRINV). An ICG sensor was also attached to the nose wing and connected to a DDG2001 analyzer for noninvasive measurement (PDRNINV). Linear regression analysis revealed PDRNINV = 0.98 PDRINV +0.11%/min (r = 0.94, p < 0.0001) with a mean bias of 0.2 +/- 2.0%/min.
Noninvasive measurements of ICG PDR are very highly correlated with values derived from an invasive fiberoptic-based reference technique.
我们研究了危重症患者中吲哚菁绿（ICG）血浆消失率（PDR）的有创（主动脉光纤）测量与无创（经皮传感器）测量之间的相关性。
在一所大学医院的外科重症监护病房进行的前瞻性临床研究。
16例危重症患者，其中成人呼吸窘迫综合征8例、脓毒症/脓毒性休克6例、蛛网膜下腔出血1例、重度颅脑损伤1例。
我们分析了16对同时进行的ICG PDR测量值。所有患者均深度镇静并接受机械通气。每位患者均置入一根带有集成光纤和热敏电阻的4F主动脉导管，该导管连接至计算机系统以自动计算有创ICG PDR（PDRINV）。一个ICG传感器也附着于鼻翼，并连接至DDG2001分析仪以进行无创测量（PDRNINV）。线性回归分析显示PDRNINV = 0.98PDRINV + 0.11%/分钟（r = 0.94，p < 0.0001），平均偏差为0.2±2.0%/分钟。
ICG PDR的无创测量值与基于有创光纤的参考技术得出的值高度相关。
