Henriksen J H, de Muckadell O B
Department of Clinical Physiology 239, Hvidovre Hospital, University of Copenhagen, Denmark.
Scand J Clin Lab Invest. 2000 Oct;60(6):463-71. doi: 10.1080/003655100448446.
The English physician E. H. Starling discovered in collaboration with the physiologist W. M. Bayliss secretin, the first hormone, in 1902. Three years later they introduced the hormone concept with recognition of chemical regulation, early regulatory physiology took a major step forward. The isolation and subsequent synthesis of secretin in the 1960s prepared the way for immunological techniques. Radioimmuno assays in the 1970s enabled demonstration of a direct endocrine role of secretin. Cloning and molecular hybridisation in the 1990s identified production site structure, precursor and evolutionary relation to other gastrointestinal peptides and to the secretin receptor. Although secretin was the first substance to be established as a hormone, even today our understanding is far from complete.
1902年，英国医生E. H. 斯塔林与生理学家W. M. 贝利斯合作发现了第一种激素——促胰液素。三年后，他们提出了激素概念，认识到化学调节作用，早期调节生理学向前迈出了重要一步。20世纪60年代促胰液素的分离及随后的合成，为免疫技术的发展铺平了道路。20世纪70年代的放射免疫测定法能够证实促胰液素的直接内分泌作用。20世纪90年代的克隆和分子杂交技术确定了促胰液素的产生部位、结构、前体以及它与其他胃肠肽和促胰液素受体的进化关系。尽管促胰液素是第一种被确认为激素的物质，但即使在今天，我们对它的了解也远未完整。
