DiGregorio Nicholas, Sharma Sandeep
Philadelphia College of Osteopathic Med
Mery Fitzgerald Hospital
In collaboration with physiologist W. M. Bayliss, English physician E. H. Starling discovered secretin in 1902. During that era, hormonal control of pancreatic secretions conflicted with the teachings of the Pavlov school that only neural reflexes were involved in pancreas response to duodenal acidification. The findings of Bayliss and Starling remain as a scientific truth, but healthcare professionals have a better-developed understanding of secretin and its function. Secretin is secreted by S cells in the duodenum and affects numerous other organ systems. Secretin receptors (SR) are expressed in the basolateral domain of several cell types. Besides regulating the growth of epithelial cells in the pancreas and biliary system, secretin additionally exerts trophic effects.
1902年，英国医生E. H. 斯塔林与生理学家W. M. 贝利斯合作发现了促胰液素。在那个时代，胰腺分泌的激素控制与巴甫洛夫学派的理论相冲突，该学派认为胰腺对十二指肠酸化的反应仅涉及神经反射。贝利斯和斯塔林的发现仍然是科学真理，但医疗保健专业人员对促胰液素及其功能有了更深入的了解。促胰液素由十二指肠中的S细胞分泌，并影响许多其他器官系统。促胰液素受体（SR）在几种细胞类型的基底外侧区域表达。除了调节胰腺和胆道系统中上皮细胞的生长外，促胰液素还具有营养作用。
