Hoffman S, Hatch M C
HIV Center for Clinical and Behavioral Studies at New York State Psychiatric Institute and Columbia University, New York 10032, USA.
Health Psychol. 2000 Nov;19(6):535-43.
The relationship between depressive symptom scores on the Center for Epidemiological Studies Depression Scale (CES-D; L. S. Radloff, 1977) at each trimester of pregnancy and a decrement in either fetal growth or gestational duration was evaluated among 666 pregnant women. There was no association overall, but among 222 women from lower occupational status households, each unit increase on the CES-D at 28 weeks gestation was associated with a reduction of 9.1 g (95% confidence interval [CI] = -16.0, -2.3) in gestational-age-adjusted birth weight. When missing data were multiply imputed, the estimate was -4.6 g (95% CI = - 10.7, 1.5). CES-D score was unrelated to fetal growth or gestational duration in analyses among other potentially high-risk subgroups: smokers, women with a history of adverse outcome, and women with social vulnerabilities. These results raise the possibility that among lower status women, depressive mood may be associated with restricted fetal growth.
在666名孕妇中，评估了孕期各阶段使用流行病学研究中心抑郁量表（CES-D；L.S.拉德洛夫，1977年）得出的抑郁症状评分与胎儿生长或孕周减少之间的关系。总体上没有关联，但在222名来自低职业地位家庭的女性中，孕28周时CES-D评分每增加一个单位，与孕周调整后的出生体重减少9.1克（95%置信区间[CI]=-16.0，-2.3）相关。当对缺失数据进行多重插补时，估计值为-4.6克（95%CI=-10.7，1.5）。在其他潜在高危亚组（吸烟者、有不良结局史的女性和有社会脆弱性的女性）的分析中，CES-D评分与胎儿生长或孕周无关。这些结果增加了一种可能性，即在社会地位较低的女性中，抑郁情绪可能与胎儿生长受限有关。
