González A, Mugueta C, Parra D, Labayen I, Martinez A, Varo N, Monreal I, Gil M J
Dpt. of Clinical Biochemistry, Clínica Universitaria de Navarra, Pamplona, Spain.
Eur J Nutr. 2000 Oct;39(5):224-8. doi: 10.1007/s003940070015.
Gastric emptying of non-nutrient liquids usually lacks the presence of an initial delay phase (lag phase), and so it has been considered to be monoexponential with an initial rapid phase followed by a slower emptying phase. However a lag phase in the gastric emptying of liquids can be found if there is a high caloric density in the liquid meal.
To characterise with stable isotopes the presence of a lag phase in the gastric emptying of non-solid meals.
Healthy volunteers ingested a low caloric liquid meal (345 KJ/ 200 mL) (LCLM), a high caloric liquid meal (1135 KJ/180 mL) (HCLM) or a semisolid meal (1403 KJ/500 mL) (SSM). Test meals were labelled with 13C-acetate. Breath samples were collected for 13CO2 measurement and data were fitted to a power exponential function.
Non-solid meals can have different behaviour related to the initial emptying. The presence of a lag phase in the gastric emptying of liquids was not masked by the processing of the tracer previous to its detection in breath. While the LCLM and SSM showed a rapid initial emptying phase (no lag phase), the HCLM has an initial slow emptying phase. The slower gastric emptying of the HCLM compared to the SSM was related to the presence of a lag phase in the gastric emptying of the HCLM.
The 13C-acetate breath test is very accurate to identify and study the lag phase if present of liquid meals.
非营养性液体的胃排空通常不存在初始延迟期（滞后相），因此被认为是单指数的，即初始快速排空期后接着较慢的排空期。然而，如果流食的热量密度较高，则可发现液体胃排空存在滞后相。
用稳定同位素表征非固体餐胃排空时滞后相的存在情况。
健康志愿者摄入低热量流食（345千焦/200毫升）（LCLM）、高热量流食（1135千焦/180毫升）（HCLM）或半固体餐（1403千焦/500毫升）（SSM）。测试餐用13C - 醋酸盐标记。收集呼气样本用于测量13CO2，并将数据拟合成幂指数函数。
非固体餐在初始排空方面可有不同表现。液体胃排空时滞后相的存在在呼气中检测到示踪剂之前的处理过程中未被掩盖。LCLM和SSM显示出快速的初始排空期（无滞后相），而HCLM有初始缓慢排空期。与SSM相比，HCLM胃排空较慢与HCLM胃排空存在滞后相有关。
13C - 醋酸盐呼气试验在识别和研究流食（若存在）的滞后相方面非常准确。
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