Herlitz J, Wiklund I, Sjöland H, Karlson B W, Karlsson T, Haglid M, Hartford M, Caidahl K
Division of Cardiology, Sahlgrenska University Hospital, Goteborg, Sweden.
Qual Life Res. 2000;9(4):467-76. doi: 10.1023/a:1008996812130.
To describe the relief of symptoms and improvement in Quality of Life (QoL) 5 years after coronary artery bypass grafting (CABG) in relation to preoperative ejection fraction (EF).
Patients who underwent CABG between 1988 and 1991 in western Sweden were approached with an inquiry prior to surgery and 5 years after the operation. Quality of Life was estimated with three different instruments: Physical activity score, Nottingham Health Profile and Psychological General Well-being Index.
Among all patients who underwent CABG (n = 1904) the 5-year mortality rate was 27% in those with EF < 0.40 and 12% in those with EF > or = 0.40 (p < 0.0001). In all, 849 patients, of whom 58 (7%) had EF < 0.40 participated in the evaluation. Neither physical activity, symptoms of chest pain, dyspnea nor any indices of QoL were significantly associated with preoperative EF. Improvement in physical activity, symptoms of chest pain and dyspnea and various estimates of QoL appeared similar and marked regardless of preoperative EF.
Among survivors there was no association between preoperative EF and symptoms or various estimates of QoL 5 years after CABG. Improvement in symptoms and QoL were not dependent on preoperative EF.
描述冠状动脉搭桥术(CABG)5年后症状缓解情况及生活质量(QoL)改善情况与术前射血分数(EF)的关系。
对1988年至1991年在瑞典西部接受CABG的患者在手术前及术后5年进行询问。使用三种不同工具评估生活质量:体力活动评分、诺丁汉健康量表和心理总体幸福感指数。
在所有接受CABG的患者中(n = 1904),EF<0.40的患者5年死亡率为27%,EF≥0.40的患者为12%(p<0.0001)。共有849例患者参与评估,其中58例(7%)EF<0.40。体力活动、胸痛症状、呼吸困难及任何生活质量指标均与术前EF无显著相关性。无论术前EF如何,体力活动、胸痛症状、呼吸困难的改善以及生活质量的各种评估结果均相似且明显。
在幸存者中,术前EF与CABG术后5年的症状或生活质量的各种评估之间无关联。症状和生活质量的改善不依赖于术前EF。