Burggraaf J, Kemme M J, Muller L M, Schoemaker R C, Cohen A F
Centre for Human Drug Research, Zernikedreef 10, 2333 CL Leiden, The Netherlands.
Br J Clin Pharmacol. 2000 Dec;50(6):621-3. doi: 10.1046/j.1365-2125.2000.00307.x.
To determine the influence of the hand circulation on the determination of venous distensibility with venous occlusion plethysmography.
In a randomised study, duplicate measurements of forearm venous distensibility, with and without a wrist cuff, were made over occlusion periods of 3 and 12 min in eight volunteers. Treatments were compared with paired Student's t-tests and differences are presented as 95% confidence intervals (CI). Intra-subject variability was assessed with analysis of variance.
Non-significant differences in increases in forearm volume between the occlusions with and without wrist cuff were found for the 3 min occlusion (CI: -0.4, + 0.2%) and the 12 min occlusion period (CI: -0.7, + 0.2%). However, the coefficient of variation was lower with the use of a wrist cuff; after 3 min occlusion (12% vs 19%) and after 12 min of occlusion (14% vs 24%). Forearm volume after 12 min of venous occlusion was 0.5% (CI: + 0.4, + 0.7) higher than after 3 min.
Although venous distensibility was equal when assessed with and without wrist cuff, exclusion of the hand circulation reduces intraindividual variability. Equilibrium in forearm volume is not reached after 3 min period of venous occlusion, as often assumed. The magnitude of the additional increase after prolonged occlusion stresses the need for well-controlled studies.
确定手部血液循环对静脉阻塞体积描记法测定静脉扩张性的影响。
在一项随机研究中，对8名志愿者在佩戴和不佩戴腕带的情况下，分别进行3分钟和12分钟阻塞期的前臂静脉扩张性重复测量。采用配对t检验比较不同处理，差异以95%置信区间（CI）表示。采用方差分析评估受试者内变异性。
在3分钟阻塞期（CI：-0.4，+0.2%）和12分钟阻塞期（CI：-0.7，+0.2%），佩戴和不佩戴腕带时前臂体积增加的差异均无统计学意义。然而，使用腕带时变异系数较低；3分钟阻塞后（12%对19%）和12分钟阻塞后（14%对24%）。静脉阻塞12分钟后的前臂体积比3分钟后高0.5%（CI：+0.4，+0.7）。
尽管佩戴和不佩戴腕带评估时静脉扩张性相同，但排除手部血液循环可降低个体内变异性。如通常所认为的，静脉阻塞3分钟后前臂体积未达到平衡。长时间阻塞后额外增加的幅度强调了进行严格对照研究的必要性。
