Tsai H P, Kuo P H, Liu C C, Wang J R
National Health Research Institutes Tainan Virology Laboratory for Diagnosis and Research, Department of Pathology, National Cheng Kung University Hospital, Tainan, Taiwan.
J Clin Microbiol. 2001 Jan;39(1):111-8. doi: 10.1128/JCM.39.1.111-118.2001.
The present study examined the association of specific virus infections with acute respiratory tract conditions among hospitalized and outpatient children in a subtropical country. A total of 2,295 virus infections were detected in 6,986 patients between 1997 and 1999, including infections caused by respiratory syncytial virus (RSV) (1.7%), parainfluenza virus (2.0%), influenza B virus (2.6%), adenovirus (4.0%), herpes simplex virus type 1 (4. 4%), influenza A virus (5.5%), and enterovirus (12.7%). There were 61 mixed infections, and no consistent seasonal variation was found. One or more viruses were detected among 24.8% of hospitalized patients and 35.0% of outpatients. The frequencies and profiles of detection of various viruses among in- and outpatients were different. The occurrence of enterovirus infections exceeded that of other viral infections detected in 1998 and 1999 due to outbreaks of enterovirus 71 and coxsackievirus A10. RSV was the most prevalent virus detected among hospitalized children, whereas influenza virus was the most frequently isolated virus in the outpatient group. Most respiratory viral infections (39.3%) occurred in children between 1 and 3 years old. RSV (P < 0.025) and influenza A virus (P < 0.05) infections were dominant in the male inpatient group. In addition, most pneumonia and bronchiolitis (48.4%) was caused by RSV among hospitalized children less than 6 months old. Adenovirus was the most common agent associated with pharyngitis and tonsilitis (45.5%). These data expand our understanding of the etiology of acute respiratory tract viral infections among in- and outpatients in a subtropical country and may contribute to the prevention and control of viral respiratory tract infections.
本研究调查了在一个亚热带国家住院和门诊儿童中特定病毒感染与急性呼吸道疾病之间的关联。1997年至1999年期间，在6986名患者中共检测到2295例病毒感染，包括呼吸道合胞病毒（RSV）（1.7%）、副流感病毒（2.0%）、乙型流感病毒（2.6%）、腺病毒（4.0%）、1型单纯疱疹病毒（4.4%）、甲型流感病毒（5.5%）和肠道病毒（12.7%）引起的感染。有61例混合感染，未发现一致的季节性变化。24.8%的住院患者和35.0%的门诊患者中检测到一种或多种病毒。住院患者和门诊患者中各种病毒的检测频率和特征不同。由于肠道病毒71型和柯萨奇病毒A10型的暴发，1998年和1999年肠道病毒感染的发生率超过了其他检测到的病毒感染。RSV是住院儿童中检测到的最常见病毒，而流感病毒是门诊组中最常分离出的病毒。大多数呼吸道病毒感染（39.3%）发生在1至3岁的儿童中。RSV（P<0.025）和甲型流感病毒（P<0.05）感染在男性住院患者组中占主导地位。此外，在6个月以下的住院儿童中，大多数肺炎和细支气管炎（48.4%）由RSV引起。腺病毒是与咽炎和扁桃体炎相关的最常见病原体（45.5%）。这些数据扩展了我们对亚热带国家住院和门诊患者急性呼吸道病毒感染病因的理解，并可能有助于预防和控制病毒性呼吸道感染。
