Clinical Data Center, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Jinsui Road, Guangzhou, 510623, Guangdong, China.
Department of Pediatric, Third People's Hospital of Shenzhen, Second Affiliated Hospital of Southern University of Science and Technology, Shenzhen, Guangdong, China.
Virol J. 2020 Dec 10;17(1):193. doi: 10.1186/s12985-020-01461-4.
The new emerging coronavirus disease 2019 (COVID-19) overall shares similar symptoms with other common respiratory viral infections. We aimed in this study to compare COVID-19 and human adenovirus (HAdV) infections in pediatric patients regarding the frequencies of major clinical symptoms and the potential disparities in laboratory and imaging parameters.
Following a case-control-like design, we built 72 age-matched pediatric COVID-19 and HAdV patient pairs. Their early symptoms and laboratory and imaging characteristics were then retrieved and compared.
Fever and cough were the most common symptoms for both infections but were seen more often in HAdV than in COVID-19 patients (92% vs. 66% and 60% vs. 18%, respectively). Compared with COVID-19 patients, children with HAdV infection had statistically significantly higher values of neutrophil count, neutrophil percentage, activated partial thromboplastin time, prothrombin time, lactate dehydrogenase, C-reactive protein, procalcitonin but lower values of lymphocyte percentage, total bilirubin, potassium and sodium. Thoracic computed tomography also revealed more anomalies in HAdV patients than in COVID-19 patients (95% vs. 67%).
COVID-19 is an overall less symptomatic and less severe infection at admission compared to HAdV respiratory infection in pediatric population.
新型冠状病毒病 2019（COVID-19）与其他常见呼吸道病毒感染总体上具有相似的症状。本研究旨在比较 COVID-19 和人类腺病毒（HAdV）感染在儿科患者中的主要临床症状频率，以及实验室和影像学参数的潜在差异。
采用病例对照设计，我们建立了 72 对年龄匹配的儿科 COVID-19 和 HAdV 患者。然后检索并比较了他们的早期症状以及实验室和影像学特征。
发热和咳嗽是两种感染的最常见症状，但 HAdV 感染患者比 COVID-19 患者更常见（92%比 66%和 60%比 18%）。与 COVID-19 患者相比，HAdV 感染患儿的中性粒细胞计数、中性粒细胞百分比、活化部分凝血活酶时间、凝血酶原时间、乳酸脱氢酶、C 反应蛋白、降钙素原明显更高，而淋巴细胞百分比、总胆红素、钾和钠明显更低。胸部计算机断层扫描也显示 HAdV 感染患儿比 COVID-19 患儿更异常（95%比 67%）。
与儿童人群中的 HAdV 呼吸道感染相比，COVID-19 在入院时总体上是一种症状较轻且较轻的感染。
