Mikami M, Kawasaki Y
Department of Internal Medicine, Kurayoshi Hospital.
Kekkaku. 2000 Nov;75(11):643-8.
This study was carried out to know the prevalence and determinants of tuberculin reactors and the size of booster phenomenon in 211 Japanese residents of a provincial nursing home for elderly. The age of the study subjects ranged from 65 to 99 (mean 83.2), and no subjects were foreign born, and had any history of BCG vaccination. The prevalence of TB infection in this aged group was estimated 70% or higher. Testing was done according to the standard method used in Japan. Results showed that 35.1% of subjects were positive by the initial test, and 27.0% converted to positive by the second test, thus altogether 52.6% were positive by two step test. No association was found between the prevalence of tuberculin positive rate and the age or the performance status. Lower body mass index, lymphocytopenia, hypoalbuminemia and PNI (prognostic nutritional index) were seen to relate with the weakened tuberculin skin reaction.
本研究旨在了解日本某省级养老院211名老年居民中结核菌素反应者的患病率、决定因素以及增强现象的程度。研究对象年龄在65岁至99岁之间(平均83.2岁),均非外国出生,且无卡介苗接种史。据估计,该老年群体中结核感染的患病率为70%或更高。检测按照日本使用的标准方法进行。结果显示,初次检测时35.1%的受试者呈阳性,二次检测时有27.0%转为阳性,因此两步检测后共有52.6%呈阳性。未发现结核菌素阳性率的患病率与年龄或身体状况之间存在关联。较低的体重指数、淋巴细胞减少、低白蛋白血症和预后营养指数与结核菌素皮肤反应减弱有关。