来自色萨利矢车菊和阿提卡矢车菊的倍半萜内酯。抗真菌活性。
Sesquiterpene lactones from Centaurea thessala and Centaurea attica. Antifungal activity.
作者信息
Skaltsa H, Lazari D, Panagouleas C, Georgiadou E, Garcia B, Sokovic M
机构信息
Department of Pharmacognosy, School of Pharmacy, University of Athens, Greece.
出版信息
Phytochemistry. 2000 Dec;55(8):903-8. doi: 10.1016/s0031-9422(00)00254-5.
The aerial parts of Centaurea thessala ssp. drakiensis and C. attica ssp. attica afforded, in addition to several known sesquiterpene lactones, two new eudesmanolides, 4-epi-sonchucarpolide and its 8-(3-hydroxy-4-acetoxy-2-methylene-butanoyloxy) derivative and one new eudesmane derivative, named atticin. The in vitro antifungal activity of most compounds was tested against nine fungal species, using the micro-dilution method. All the compounds tested showed great antifungal activity.
除了几种已知的倍半萜内酯外，色萨利矢车菊亚种 drakiensis 和阿提卡矢车菊亚种 attica 的地上部分还提供了两种新的桉烷型倍半萜内酯，4-表-苦苣菜内酯及其8-(3-羟基-4-乙酰氧基-2-亚甲基丁酰氧基)衍生物，以及一种名为阿提卡素的新桉烷衍生物。使用微量稀释法对大多数化合物的体外抗真菌活性进行了针对九种真菌的测试。所有测试的化合物都显示出很强的抗真菌活性。
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