Oteri Giacomo, Lentini Maria, Pisano Michele, Cicciù Marco
Department of Biomedical Sciences and Specialist Medical-Surgical Dentistry.
Department of Human Pathology, University of Messina, Italy.
Open Dent J. 2014 Sep 29;8:159-63. doi: 10.2174/1874210601408010159. eCollection 2014.
The Extraosseous or Peripheral Ameloblastoma (PA) is a rare and benign odontogenic tumour, representing 1% to 5% of all ameloblastomas. It is usually localized in the soft oral tissues, without deep bone involvement. Its biological behaviour is specific, and several authors define PA as a non-infiltrating hamartomatous lesion. Indeed, recurrences rarely occur and progression in malignant tumors appears to be rare. The PA originates from the tooth-forming apparatus and it consists of proliferating odontogenic epithelium, exhibiting the same histological cell types and patterns of the intraosseous counterpart or infiltrating ameloblastoma. The peripheral desmoplastic ameloblastoma (PDA) can be classified as a newly recognized and very rare histological variant. To our knowledge, only a few cases of adult patients affected by PDA have been published. The aim of this paper is to report a case of PDA affecting an adolescent patient. The clinical-pathological and immunohistological features are discussed in order to improve knowledge regarding a correct diagnosis and to differentiate PDA lesions from similar diseases.
骨外型或外周型成釉细胞瘤（PA）是一种罕见的良性牙源性肿瘤，占所有成釉细胞瘤的1%至5%。它通常局限于口腔软组织，不累及深部骨骼。其生物学行为具有特异性，一些作者将PA定义为非浸润性错构瘤样病变。事实上，复发很少发生，恶性肿瘤进展似乎也很少见。PA起源于牙齿形成器官，由增生的牙源性上皮组成，表现出与骨内型或浸润性成釉细胞瘤相同的组织学细胞类型和模式。外周促结缔组织增生性成釉细胞瘤（PDA）可归类为一种新认识的非常罕见的组织学变异型。据我们所知，仅有少数成年患者患PDA的病例被报道。本文旨在报告一例影响青少年患者的PDA病例。对其临床病理和免疫组织学特征进行讨论，以增进对正确诊断的认识，并将PDA病变与相似疾病相鉴别。
