Sheu J H, Hung K C, Wang G H, Duh C Y
Department of Marine Resources, National Sun Yat-Sen University, Kaohsiung, Taiwan 804, Republic of China.
J Nat Prod. 2000 Dec;63(12):1603-7. doi: 10.1021/np000271n.
Five new suberosane sesquiterpenes, suberosenol A (1), suberosenol B (2), suberosanone (3), suberosenol A acetate (4), and suberosenol B acetate (5), along with the known sesquiterpene subergorgic acid (6), have been isolated from the gorgonian Isis hippuris. The structures of these metabolites were established by spectroscopic and chemical methods. Metabolites 1 and 3-5 were found to exhibit potent cytotoxicity toward P-388, A549, and HT-29 cancer cell lines.
从柳珊瑚Isis hippuris中分离出了五种新的软木烷倍半萜，即软木烯醇A（1）、软木烯醇B（2）、软木烯酮（3）、软木烯醇A乙酸酯（4）和软木烯醇B乙酸酯（5），以及已知的倍半萜软珊瑚酸（6）。这些代谢产物的结构通过光谱和化学方法确定。发现代谢产物1和3 - 5对P - 388、A549和HT - 29癌细胞系具有强大的细胞毒性。
