来自柳珊瑚Isis hippuris的多氧化甾体

Polyoxygenated steroids from the gorgonian Isis hippuris.

作者信息

Chao Chih-Hua, Huang Long-Fei, Yang Yi-Lea, Su Jui-Hsin, Wang Guey-Horng, Chiang Michael Y, Wu Yang-Chang, Dai Chang-Feng, Sheu Jyh-Horng

机构信息

Department of Marine Resources, National Sun Yat-Sen University, Taiwan, Republic of China.

出版信息

J Nat Prod. 2005 Jun;68(6):880-5. doi: 10.1021/np050033y.

DOI:10.1021/np050033y

PMID:15974612

Abstract

Eleven new hippuristanols (1-4, 7-9, and 11-14), along with eight known metabolites (5, 6, 10, and 15-19), have been isolated from the gorgonian coral Isis hippuris. Single-crystal X-ray diffraction analyses supported the structure elucidation of known steroids 5 and 10. The absolute structures of hippuristanols were established by application of modified Mosher's method on 19. Compounds 14-19 have been found to exhibit significant cytotoxicity against several cancer cell lines.

摘要

从柳珊瑚Isis hippuris中分离出了11种新的马尿酸甾醇（1-4、7-9和11-14），以及8种已知的代谢产物（5、6、10和15-19）。单晶X射线衍射分析支持了已知甾体5和10的结构解析。通过对19应用改良的莫舍尔方法确定了马尿酸甾醇的绝对结构。已发现化合物14-19对几种癌细胞系表现出显著的细胞毒性。