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[因误服食盐导致的致命性高钠血症]

[Fatal hypernatremia due to accidental administration of table salt].

作者信息

Martos Sánchez I, Ros Pérez P, Otheo de Tejada E, Vázquez Martínez J L, Pérez-Caballero C, Fernández Pineda L

机构信息

Unidad de Cuidados Intensivos Pediátrica. Hospital Ramón y Cajal. Madrid.

出版信息

An Esp Pediatr. 2000 Nov;53(5):495-8.

Abstract

Hypernatremia is a common electrolyte abnormality, but it is rarely attributable to excess sodium. Hypernatremia due to exogenous salt intake, caused either by accidental ingestion or as a form of child abuse, is rare, difficult to manage and results in high mortality. Although hypernatremia is easily recognized by laboratory tests, its etiology is often difficult to determine. A surprisingly small amount of salt intake can result in a fatal outcome. We report two cases of severe salt intoxication in two girls, aged 20 and 7 months, who presented with severe hypernatremia. Both had seizures after accidental salt ingestion. In the first case, salt instead of sugar was inadvertently added to two yoghurts, leading to hypernatremia and convulsions. In the second case, a mistake in the preparation of salt-saturated water as an oral rehydration solution provoked seizures, coagulopathy and longitudinal venous sinus thrombosis. Both cases developed encephalic death. We discuss the clinical course and the difficulties in the treatment of these cases in the context of the available literature.

摘要

高钠血症是一种常见的电解质异常,但很少由钠摄入过多引起。因意外摄入或作为虐待儿童形式导致的外源性盐摄入引起的高钠血症罕见、难以处理且死亡率高。尽管高钠血症通过实验室检查很容易识别,但其病因往往难以确定。令人惊讶的是,少量的盐摄入也可能导致致命后果。我们报告了两例严重盐中毒病例,两名女孩分别为20岁和7个月大,均表现为严重高钠血症。两人均在意外摄入盐后出现癫痫发作。第一例中,无意中将盐而非糖添加到两份酸奶中,导致高钠血症和惊厥。第二例中,在制备盐饱和水作为口服补液溶液时出现失误,引发了癫痫发作、凝血病和纵向静脉窦血栓形成。两例均发展为脑死亡。我们结合现有文献讨论了这些病例的临床过程及治疗难点。

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