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新生儿因盐摄入过多导致的严重高钠血症。

Severe hypernatremia in newborns due to salting.

机构信息

Department of Pediatrics, Division of Neonatology, School of Medicine, Yuzuncu Yil University, Van, Turkey.

出版信息

Eur J Pediatr. 2010 Jul;169(7):829-32. doi: 10.1007/s00431-009-1123-9. Epub 2009 Dec 17.

Abstract

The aim of this study was to evaluate the etiology, clinical, and laboratory findings and prognostic features of life-threatening hypernatremic newborns secondary to salting. Ten severely hypernatremic newborns (four females) with a mean age of 6.5 +/- 2.6 days were followed up. Nine of them were full term, and one was preterm. It was noticeable that 60% of them were small for gestational age. In the laboratory investigation, five uremias were detected. It was interesting to find in the etiologic history that 40% of the patients had been salted just after birth. Twenty percent of them had also hyperbilirubinemia and kernicterus, 20% had neonatal convulsion, and 50% had dehydration. Two of the hypernatremic newborns died during the study; the others were followed up. One case had spasticity and developmental disability at the 3rd month, and another one had developmental disability at the 6th month of ages. As a conclusion, although salting of newborns is not so frequent, it could be seen in rural places of our country, and this may be one of the reasons for serious hypernatremia in newborns whose skin integrity have not been formed completely. These cases should be treated carefully.

摘要

本研究旨在评估危及生命的高钠血症新生儿盐中毒的病因、临床和实验室发现及预后特征。对 10 名严重高钠血症新生儿(4 名女性)进行了随访,平均年龄为 6.5 +/- 2.6 天。其中 9 名是足月儿,1 名是早产儿。值得注意的是,60%的患儿为小于胎龄儿。在实验室检查中,发现 5 例存在尿毒症。在病因学方面,有趣的是发现 40%的患儿在出生后不久就接受了盐疗。其中 20%的患儿还伴有高胆红素血症和核黄疸,20%的患儿有新生儿抽搐,50%的患儿有脱水。在研究期间,有 2 名高钠血症新生儿死亡,其余患儿进行了随访。1 例在 3 个月时出现痉挛和发育障碍,另 1 例在 6 个月时出现发育障碍。总之,尽管新生儿盐疗并不常见,但在我国农村地区可能会出现,这可能是新生儿严重高钠血症的原因之一,因为这些新生儿的皮肤完整性尚未完全形成。这些病例应谨慎治疗。

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