植物甾醇与胃癌风险：乌拉圭的一项病例对照研究

Plant sterols and risk of stomach cancer: a case-control study in Uruguay.

作者信息

De Stefani E, Boffetta P, Ronco A L, Brennan P, Deneo-Pellegrini H, Carzoglio J C, Mendilaharsu M

机构信息

Registro Nacional de Cáncer, Montevideo, Uruguay.

出版信息

Nutr Cancer. 2000;37(2):140-4. doi: 10.1207/S15327914NC372_4.

DOI:10.1207/S15327914NC372_4

PMID:11142085

Abstract

In 1997-1999, 120 incident and histologically verified cases of stomach cancer were frequency matched on age, gender, residence, and urban/rural status with 360 controls to study the role of diet in gastric cancer in Uruguay. We focused on the role of plant sterols (beta-sitosterol, campesterol, stigmasterol, and total plant sterols) after controlling for major confounders. Total phytosterols were associated with a strong inverse relationship with stomach cancer (odds ratio of stomach cancer for total phytosterol intake in the highest tertile = 0.33, 95% confidence interval = 0.17-0.65). Joint exposure to high intake of total phytosterol and alpha-carotene was also inversely associated with gastric cancer risk (odds ratio = 0.09, 95% confidence interval = 0.02-0.32). High intake of total plant sterols explained most of the attenuation in risk of gastric cancer associated with vegetable and fruit intakes.

摘要

1997年至1999年期间，对120例新发病例且经组织学确诊的胃癌患者，按照年龄、性别、居住地及城乡身份与360名对照进行频数匹配，以研究乌拉圭饮食在胃癌发病中的作用。在控制了主要混杂因素后，我们重点关注植物甾醇（β-谷甾醇、菜油甾醇、豆甾醇及总植物甾醇）的作用。总植物甾醇与胃癌呈强烈负相关（总植物甾醇摄入量处于最高三分位数时患胃癌的比值比=0.33，95%置信区间=0.17-0.65）。总植物甾醇和α-胡萝卜素的高摄入量共同暴露也与胃癌风险呈负相关（比值比=0.09，95%置信区间=0.02-0.32）。总植物甾醇的高摄入量解释了大部分与蔬菜和水果摄入量相关的胃癌风险降低情况。