Deneo-Pellegrini H, De Stefani E, Ronco A
Registro Nacional de Cancer, Instituto Nacional de Oncologia, Montevideo, Uruguay.
Nutr Cancer. 1996;25(3):297-304. doi: 10.1080/01635589609514453.
To examine whether vegetable and fruit intake modify colorectal cancer risk, a case-control study was conducted in Uruguay. Dietary patterns were assessed in detail (for cases before diagnosis or symptoms occurred) by use of a food frequency questionnaire on 61 food items, which allowed the calculation of total energy intake. Nutrient residuals were calculated through regression analysis. After adjustment for potential confounders (which included body mass index, total energy, and total alcohol intake), a reduction in risk for total vegetable intake, total fruit intake, and lettuce, apple, and banana consumption was observed. The strongest protection was observed for banana intake (odds ratio 0.28; 95% confidence level 0.16-0.50) for consumption in the third tertile compared with the first.
为了研究蔬菜和水果摄入量是否会改变结直肠癌风险，在乌拉圭开展了一项病例对照研究。通过一份包含61种食物的食物频率问卷（在病例出现诊断或症状之前）详细评估饮食模式，该问卷可用于计算总能量摄入量。通过回归分析计算营养素残差。在对潜在混杂因素（包括体重指数、总能量和总酒精摄入量）进行调整后，观察到总蔬菜摄入量、总水果摄入量以及生菜、苹果和香蕉摄入量的风险降低。与第一三分位数相比，第三三分位数的香蕉摄入量观察到最强的保护作用（优势比0.28；95%置信区间0.16 - 0.50）。
