补充α-生育酚和β-胡萝卜素对尿路癌的影响：一项对照试验（芬兰）中的发病率和死亡率

Effects of supplemental alpha-tocopherol and beta-carotene on urinary tract cancer: incidence and mortality in a controlled trial (Finland).

作者信息

Virtamo J, Edwards B K, Virtanen M, Taylor P R, Malila N, Albanes D, Huttunen J K, Hartman A M, Hietanen P, Mäenpää H, Koss L, Nordling S, Heinonen O P

机构信息

National Public Health Institute, Helsinki, Finland.

出版信息

Cancer Causes Control. 2000 Dec;11(10):933-9. doi: 10.1023/a:1026546803917.

DOI:10.1023/a:1026546803917

PMID:11142528

Abstract

OBJECTIVES

Epidemiological studies have suggested a protective effect of vegetables and fruits on urinary tract cancer but the possible protective nutrients are unknown. We studied the effect of alpha-tocopherol (a form of vitamin E) and beta-carotene supplementation on urinary tract cancer in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Study.

METHODS

A total of 29,133 male smokers aged 50-69 years from southwestern Finland were randomly assigned to receive alpha-tocopherol (50 mg), beta-carotene (20 mg), both agents, or a placebo daily for 5-8 years (median 6.1 years). Incident urothelial cancers (bladder, ureter, and renal pelvis; n = 169) and renal cell cancers (n = 102) were identified through the nationwide cancer registry. The diagnoses were centrally confirmed by review of medical records and pathology specimens. The supplementation effects were estimated using a proportional hazards model.

RESULTS

Neither alpha-tocopherol nor beta-carotene affected the incidence of urothelial cancer, relative risk 1.1 (95% confidence interval (CI) 0.8-1.5) and 1.0 (95% CI 0.7-1.3), respectively, or the incidence of renal cell cancer, relative risk 1.1 (95% CI 0.7-1.6) and 0.8 (95% CI 0.6-1.3), respectively.

CONCLUSION

Long-term supplementation with alpha-tocopherol and beta-carotene has no preventive effect on urinary tract cancers in middle-aged male smokers.

摘要

目的

流行病学研究表明蔬菜和水果对尿路癌具有保护作用，但可能的保护性营养素尚不清楚。我们在α-生育酚、β-胡萝卜素癌症预防（ATBC）研究中，研究了补充α-生育酚（维生素E的一种形式）和β-胡萝卜素对尿路癌的影响。

方法

来自芬兰西南部的29133名年龄在50 - 69岁的男性吸烟者被随机分配，每天接受α-生育酚（50毫克）、β-胡萝卜素（20毫克）、两种药物或安慰剂，持续5 - 8年（中位数6.1年）。通过全国癌症登记处确定了新发的尿路上皮癌（膀胱、输尿管和肾盂；n = 169）和肾细胞癌（n = 102）。通过审查医疗记录和病理标本对诊断进行集中确认。使用比例风险模型估计补充剂的效果。