Malila Nea, Taylor Philip R, Virtanen Mikko J, Korhonen Pasi, Huttunen Jussi K, Albanes Demetrius, Virtamo Jarmo
National Public Health Institute, Helsinki, Finland.
Cancer Causes Control. 2002 Sep;13(7):617-23. doi: 10.1023/a:1019556227014.
This study investigated the effects of alpha-tocopherol and beta-carotene supplementation on the incidence of gastric cancer.
A total of 29,133 male smokers, aged 50-69 years, participated in a placebo-controlled prevention trial, the Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Study in southwestern Finland between 1985 and 1993. The men were randomly assigned to receive alpha-tocopherol (50 mg/day) or beta-carotene (20 mg/day) supplementation in a 2 x 2 factorial design. We identified 126 gastric cancer cases during the median follow-up of six years. Of these, 122 were adenocarcinomas: 75 of intestinal type, 30 of diffuse type, and 17 of mixed type.
There was no significant effect for either supplementation on the overall incidence of gastric cancer: relative risk (RR) 1.21, 95% confidence interval (CI) 0.85-1.74 for alpha-tocopherol, and RR 1.26, 95% Cl 0.88-1.80 for beta-carotene. Subgroup analyses by histologic type suggested an increased risk for beta-carotene on intestinal type cancers, RR 1.59, 95% CI 0.99-2.56. There were no differences across anatomic locations (cardia/noncardia) in the effects of alpha-tocopherol or beta-carotene supplementation.
Our study found no overall preventive effect of long-term supplementation with alpha-tocopherol or beta-carotene on gastric cancer in middle-aged male smokers.
本研究调查了补充α-生育酚和β-胡萝卜素对胃癌发病率的影响。
1985年至1993年期间，共有29133名年龄在50 - 69岁的男性吸烟者参与了一项安慰剂对照预防试验，即芬兰西南部的α-生育酚、β-胡萝卜素癌症预防（ATBC）研究。这些男性被随机分配，按照2×2析因设计接受α-生育酚（50毫克/天）或β-胡萝卜素（20毫克/天）补充剂。在中位随访六年期间，我们确定了126例胃癌病例。其中，122例为腺癌：75例为肠型，30例为弥漫型，17例为混合型。
两种补充剂对胃癌总体发病率均无显著影响：α-生育酚的相对风险（RR）为1.21，95%置信区间（CI）为0.85 - 1.74；β-胡萝卜素的RR为1.26，95% CI为0.88 - 1.80。按组织学类型进行的亚组分析表明，β-胡萝卜素对肠型癌症的风险增加，RR为1.59，95% CI为0.99 - 2.56。α-生育酚或β-胡萝卜素补充剂在不同解剖部位（贲门/非贲门）的影响没有差异。
我们的研究发现，长期补充α-生育酚或β-胡萝卜素对中年男性吸烟者的胃癌没有总体预防作用。
