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微孢子虫与获得性免疫缺陷综合征

Microsporidia and acquired immunodeficiency syndrome.

作者信息

Schottelius J, da Costa S C

机构信息

Section of Parasitology, Bernhard-Nocht-Institute for Tropical Medicine, D-20359 Hamburg, Germany.

出版信息

Mem Inst Oswaldo Cruz. 2000;95 Suppl 1:133-9. doi: 10.1590/s0074-02762000000700022.

DOI:10.1590/s0074-02762000000700022
PMID:11142702
Abstract

Microsporidia is a common term that has been used to refer to a group of eukaryotic, obligate intracellular protozoan parasites belonging to the phylum Microspora. They are important agricultural parasites, contaminating commercial insects; they are also important by infecting laboratory rodents, rabbits and primates. Ever since the early cases found by Magarino Torres, who reported the presence of Encephalitozoon in a patient suffering of a meningoencephalomyelitis, some human pathology caused by microsporidia has been described. However, only after the acquired immunodeficiency syndrome outbreak have these organisms appeared as significant etiological agents in different pathologies. Even so, they remain underestimated. In the present article, the importance of microsporidia for the human pathology in immunocompromised host has been stressed.

摘要

微孢子虫是一个常用术语,用于指代一群属于微孢子虫门的真核、专性细胞内原生动物寄生虫。它们是重要的农业寄生虫,会污染商业养殖昆虫;它们还通过感染实验用啮齿动物、兔子和灵长类动物而具有重要意义。自从马加里诺·托雷斯发现早期病例以来,他报告了一名患有脑膜脑脊髓炎的患者体内存在脑孢子虫,此后已有一些由微孢子虫引起的人类病理情况被描述。然而,直到获得性免疫缺陷综合征爆发后,这些生物体才在不同病理中成为重要的病原体。即便如此,它们仍然被低估。在本文中,强调了微孢子虫对免疫功能低下宿主的人类病理学的重要性。

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Microsporidia and acquired immunodeficiency syndrome.微孢子虫与获得性免疫缺陷综合征
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Microsporidiosis: molecular and diagnostic aspects.微孢子虫病:分子与诊断方面
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Microsporidia: emerging advances in understanding the basic biology of these unique organisms.微孢子虫:在理解这些独特生物体基本生物学方面的新进展
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Toll-like receptor 2 recognition of the microsporidia Encephalitozoon spp. induces nuclear translocation of NF-kappaB and subsequent inflammatory responses.Toll样受体2对微孢子虫属脑胞内原虫的识别可诱导核因子κB的核转位及随后的炎症反应。
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