N-甲基山柰酰胺，一种从镰刀菌属海洋真菌中提取的具有细胞毒性的环缩肽。
N-Methylsansalvamide, a cytotoxic cyclic depsipeptide from a marine fungus of the genus fusarium.
作者信息
Cueto M, Jensen P R, Fenical W
机构信息
Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oeanography, University of California, San Diego, La Jolla 92093-0204, USA.
出版信息
Phytochemistry. 2000 Oct;55(3):223-6. doi: 10.1016/s0031-9422(00)00280-6.
Abstract
N-Methylsansalvamide (1), a new cyclic depsipeptide, was isolated from extracts of a cultured marine fungus, strain CNL-619, identified as a member of the genus Fusarium. N-Methylsansalvamide exhibits weak in vitro cytotoxicity in the NCI human tumor cell line screen (GI50 8.3 microM). The structure of 1 was determined by combined spectral and chemical methods.
摘要
N-甲基无叶假木贼酰胺（1）是一种新的环缩肽，从一株被鉴定为镰刀菌属成员的海洋真菌菌株CNL-619的培养提取物中分离得到。N-甲基无叶假木贼酰胺在NCI人类肿瘤细胞系筛选中表现出较弱的体外细胞毒性（GI50为8.3微摩尔）。通过光谱和化学方法相结合确定了1的结构。
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