来自伞花红树的细胞毒性克罗烷二萜酯。

Cytotoxic clerodane diterpene esters from Laetia corymbulosa.

作者信息

Beutler J A, McCall K L, Herbert K, Johnson T, Shoemaker R H, Boyd M R

机构信息

Laboratory of Drug Discovery Research & Development, National Cancer Institute, Frederick Cancer Reasearch and Development Center, MD 21702-1201, USA.

出版信息

Phytochemistry. 2000 Oct;55(3):233-6. doi: 10.1016/s0031-9422(00)00281-8.

DOI:10.1016/s0031-9422(00)00281-8

PMID:11142848

Abstract

Three cytotoxic clerodane diterpene esters, corymbulosins A-C, were isolated from an organic extract of the fruit of Laetia corymbulosa (Flacourtiaceae) from Peru. The structures were determined by spectroscopic methods as clerodane diterpenes unsaturated at C-3, C-13(16) and C-14. Corymbulosin A was esterified at C-2 with a decadienoate moiety, while corymbulosins B and C were C-2 epimers esterified at C-6 with a decanoate moiety.

摘要

从秘鲁的伞花拉埃梯木（大风子科）果实的有机提取物中分离出三种具有细胞毒性的克罗烷二萜酯，即伞花素A - C。通过光谱方法确定其结构为在C-3、C-13(16)和C-14处不饱和的克罗烷二萜。伞花素A在C-2处被一个癸二烯酸酯部分酯化，而伞花素B和C是在C-6处被一个癸酸酯部分酯化的C-2差向异构体。