天然枞烷、贝壳杉烷和 clerodane 二萜作为抗癌剂的研究进展：来源和作用机制。

Department of Drug and Health Sciences, University of Catania, Viale A. Doria, 95125 Catania, Italy.

CERNUT, Research Centre on Nutraceuticals and Health Products, Department of Drug and Health Sciences, University of Catania, Viale A. Doria, 95125 Catania, Italy.

Molecules. 2022 Jul 26;27(15):4791. doi: 10.3390/molecules27154791.

Extensive research over the past decades has identified numerous phytochemicals that could represent an important source of anti-cancer compounds. There is an immediate need for less toxic and more effective preventive and therapeutic strategies for the treatment of cancer. Natural compounds are considered suitable candidates for the development of new anti-cancer drugs due to their pleiotropic actions on target events with multiple manners. This comprehensive review highlighted the most relevant findings achieved in the screening of phytochemicals for anticancer drug development, particularly focused on a promising class of phytochemicals such as diterpenes with abietane, clerodane, and labdane skeleton. The chemical structure of these compounds, their main natural sources, and mechanisms of action were critically discussed.

在过去几十年的广泛研究中，已经鉴定出许多植物化学物质，它们可能是抗癌化合物的重要来源。目前迫切需要寻找毒性更低、更有效的预防和治疗癌症的策略。由于天然化合物对具有多种方式的靶事件具有多种作用，因此被认为是开发新型抗癌药物的合适候选物。本综述重点介绍了在筛选用于抗癌药物开发的植物化学物质方面取得的最相关发现，特别是聚焦于具有松香烷、克来烷和贝壳杉烷骨架的二萜等一类很有前途的植物化学物质。本文批判性地讨论了这些化合物的化学结构、主要天然来源和作用机制。