来自巴恩氏暗罗的细胞毒性克罗烷二萜类化合物。

Cytotoxic clerodane diterpenes from Polyalthia barnesii.

作者信息

Ma X, Lee I S, Chai H B, Zaw K, Farnsworth N R, Soejarto D D, Cordell G A, Pezzuto J M, Kinghorn A D

机构信息

Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago 60612, USA.

出版信息

Phytochemistry. 1994 Dec;37(6):1659-62. doi: 10.1016/s0031-9422(00)89587-4.

DOI:10.1016/s0031-9422(00)89587-4

PMID:7766002

Abstract

Three cytotoxic clerodane diterpenes were purified from an ethyl acetate-soluble extract of the stem bark of Polyalthia barnesii, namely, 16 alpha-hydroxycleroda-3,13(14)Z-dien-15,16-olide, a known compound, and two novel compounds, 3 beta, 16 alpha-dihydroxycleroda-4(18),13(14)Z-dien-15,16-olide and 4 beta, 16 alpha-dihydroxyclerod-13(14)Z-en-15,16-olide. These compounds were found to exhibit broad cytotoxicity against a panel of human cancer cell lines.

摘要

从巴恩氏暗罗茎皮的乙酸乙酯可溶提取物中纯化出三种具有细胞毒性的克罗烷二萜，即一种已知化合物16α-羟基克罗达-3,13(14)Z-二烯-15,16-内酯，以及两种新化合物3β,16α-二羟基克罗达-4(18),13(14)Z-二烯-15,16-内酯和4β,16α-二羟基克罗达-13(14)Z-烯-15,16-内酯。发现这些化合物对一组人类癌细胞系具有广泛的细胞毒性。